Inhibition by Colchicine of the Mitogenic Stimulation of Lymphocytes Prior to the S Phase

Colchicine, vinblastine, and vincristine inhibit the mitogenic stimulation of lymphocytes by concanavalin A as measured by the incorporation of [3H]thymidine and the appearance of blast cells. The inhibitory effect of colchicine could not be accounted for by diminution in cell viability or by metaph...

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Veröffentlicht in:	The Journal of cell biology 1975-07, Vol.66 (1), p.128-144
Hauptverfasser:	Wang, John L., Gunther, Gary R., Edelman, Gerald M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoradiography B lymphocytes Blasts Cell culture techniques Cells Cells, Cultured Colchicine - pharmacology Concanavalin A - pharmacology Cultured cells Daughter cells DNA - biosynthesis Drug Antagonism Humans Kinetics Lymphocyte Activation - drug effects Lymphocytes Lymphocytes - drug effects Lymphocytes - metabolism Mast cells Methylmannosides - pharmacology Mice Phagocytes Rabbits Thymidine - metabolism Tritium Vinblastine - pharmacology Vincristine - pharmacology
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