The Tumor-Promoter Phorbol Ester (12-0-Tetradecanoyl-Phorbol-13-Acetate), a Potent Aggregating Agent for Blood Platelets

The phorbol ester 12-0-tetradecanoyl-phorbol-13-acetate, a potent tumor-promoting agent, caused irreversible platelet aggregation when more than 0.02 μM was stirred with human citrated or heparinized platelet-rich plasma (PRP). With washed platelets, 1 nM was effective. The alcohol phorbol, which ha...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of cell biology 1974-02, Vol.60 (2), p.325-336
Hauptverfasser:	Zucker, Marjorie B., Troll, Walter, Belman, Sidney
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacology Aggregation Alcohols - pharmacology Blood Blood Platelets - cytology Blood Platelets - drug effects Blood Platelets - metabolism Bucladesine - pharmacology Carbon Radioisotopes Carcinogens - pharmacology Cell biology Chelating Agents - pharmacology Cyanides - pharmacology Cyclic AMP - metabolism Dehydrogenases Dimethyl Sulfoxide - pharmacology Diterpenes - pharmacology Enzymes Esters Fatty Acids - pharmacology Humans Low concentrations Microscopy, Phase-Contrast Phorbol esters Phorbols Phosphocreatine - pharmacology Phosphotransferases - metabolism Platelet Adhesiveness - drug effects Platelets Prostaglandins - pharmacology Serotonin - metabolism Temperature Theophylline - pharmacology Time Factors Tosyl Compounds - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!