The Fine Structure of Astrocytes in the Cerebral Cortex and Their Response to Focal Injury Produced by Heavy Ionizing Particles
Normal and reactive astrocytes in the cerebral cortex of the rat have been studied with the electron microscope following focal alpha particle irradiation. The presence of glycogen and approximately 60-A fibrils identify astrocyte cytoplasm in formalin-perfused tissue. The glycogen particles facilit...
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| Veröffentlicht in: | Journal of Cell Biology (U.S.) Formerly J. Biophys. Biochem. Cytol 1965-05, Vol.25 (2), p.141-157 |
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| container_title | Journal of Cell Biology (U.S.) Formerly J. Biophys. Biochem. Cytol |
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| creator | Maxwell, David S. Kruger, Lawrence |
| description | Normal and reactive astrocytes in the cerebral cortex of the rat have been studied with the electron microscope following focal alpha particle irradiation. The presence of glycogen and approximately 60-A fibrils identify astrocyte cytoplasm in formalin-perfused tissue. The glycogen particles facilitate the identification of small processes and subpial and perivascular end-feet. Both protoplasmic and fibrous astrocytes contain cytoplasmic fibrils and should be distinguished on the basis of the configuration of their processes and their distribution. Acutely reactive astrocytes are characterized by a marked increase in the number of glycogen granules and mitochondria from the first day after irradiation. These cells later hypertrophy and accumulate lipid bodies and increased numbers of cytoplasmic fibrils. The glial "scar" consists of a greatly expanded volume of astrocyte cytoplasm filled with fibrils and displays no signs of astrocyte death, reversion to primitive forms, or extensive multiplication. |
| doi_str_mv | 10.1083/jcb.25.2.141 |
| format | Article |
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The presence of glycogen and approximately 60-A fibrils identify astrocyte cytoplasm in formalin-perfused tissue. The glycogen particles facilitate the identification of small processes and subpial and perivascular end-feet. Both protoplasmic and fibrous astrocytes contain cytoplasmic fibrils and should be distinguished on the basis of the configuration of their processes and their distribution. Acutely reactive astrocytes are characterized by a marked increase in the number of glycogen granules and mitochondria from the first day after irradiation. These cells later hypertrophy and accumulate lipid bodies and increased numbers of cytoplasmic fibrils. The glial "scar" consists of a greatly expanded volume of astrocyte cytoplasm filled with fibrils and displays no signs of astrocyte death, reversion to primitive forms, or extensive multiplication.</description><identifier>ISSN: 0021-9525</identifier><identifier>EISSN: 1540-8140</identifier><identifier>DOI: 10.1083/jcb.25.2.141</identifier><identifier>PMID: 19866658</identifier><language>eng</language><publisher>United States: Rockefeller Institute Press</publisher><subject>ALPHA BEAMS ; ANIMAL CELLS ; ASTROCYTES ; BIOLOGY AND MEDICINE ; BRAIN ; Cerebral cortex ; CONFIGURATION ; CYTOLOGY ; Cytoplasm ; Electron microscopy ; Glycogen ; Irradiation ; Lesions ; MALFORMATIONS ; NERVOUS SYSTEM ; Neuroglia ; Radiation dosage ; Radiation Effects ; RADIATION INJURIES ; Solar fibrils ; TISSUES</subject><ispartof>Journal of Cell Biology (U.S.) Formerly J. Biophys. Biochem. Cytol, 1965-05, Vol.25 (2), p.141-157</ispartof><rights>Copyright © 1965 by The Rockefeller Institute Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-1183db737b25ebcc7985eb437e412ca09d37af02b9eb72bfc3ef5543f1a36da53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19866658$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/4601243$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Maxwell, David S.</creatorcontrib><creatorcontrib>Kruger, Lawrence</creatorcontrib><creatorcontrib>Univ. of California, Los Angeles</creatorcontrib><creatorcontrib>and Veterans Administration Hospital, Long Beach, Calif</creatorcontrib><title>The Fine Structure of Astrocytes in the Cerebral Cortex and Their Response to Focal Injury Produced by Heavy Ionizing Particles</title><title>Journal of Cell Biology (U.S.) Formerly J. Biophys. Biochem. Cytol</title><addtitle>J Cell Biol</addtitle><description>Normal and reactive astrocytes in the cerebral cortex of the rat have been studied with the electron microscope following focal alpha particle irradiation. The presence of glycogen and approximately 60-A fibrils identify astrocyte cytoplasm in formalin-perfused tissue. The glycogen particles facilitate the identification of small processes and subpial and perivascular end-feet. Both protoplasmic and fibrous astrocytes contain cytoplasmic fibrils and should be distinguished on the basis of the configuration of their processes and their distribution. Acutely reactive astrocytes are characterized by a marked increase in the number of glycogen granules and mitochondria from the first day after irradiation. These cells later hypertrophy and accumulate lipid bodies and increased numbers of cytoplasmic fibrils. The glial "scar" consists of a greatly expanded volume of astrocyte cytoplasm filled with fibrils and displays no signs of astrocyte death, reversion to primitive forms, or extensive multiplication.</description><subject>ALPHA BEAMS</subject><subject>ANIMAL CELLS</subject><subject>ASTROCYTES</subject><subject>BIOLOGY AND MEDICINE</subject><subject>BRAIN</subject><subject>Cerebral cortex</subject><subject>CONFIGURATION</subject><subject>CYTOLOGY</subject><subject>Cytoplasm</subject><subject>Electron microscopy</subject><subject>Glycogen</subject><subject>Irradiation</subject><subject>Lesions</subject><subject>MALFORMATIONS</subject><subject>NERVOUS SYSTEM</subject><subject>Neuroglia</subject><subject>Radiation dosage</subject><subject>Radiation Effects</subject><subject>RADIATION INJURIES</subject><subject>Solar fibrils</subject><subject>TISSUES</subject><issn>0021-9525</issn><issn>1540-8140</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1965</creationdate><recordtype>article</recordtype><recordid>eNpVkc1vEzEQxS0EomnhxhEhi0svbPDnflyQqojQSJWooJwt2zvbONrYwfZWLBf-dYwSUTjN4f3mzRs9hF5RsqSk5e931iyZXLIlFfQJWlApSNVSQZ6iBSGMVp1k8gydp7QjhIhG8OfojHZtXdeyXaBfd1vAa-cBf81xsnmKgMOAr1KOwc4ZEnYe58KsIIKJesSrEDP8wNr3uOy6iL9AOgSfAOeA18EWZON3U5zxbQz9ZKHHZsbXoB9mvAne_XT-Ht_qmJ0dIb1AzwY9Jnh5mhfo2_rj3eq6uvn8abO6uqms4DRXlLa8Nw1vDJNgrG26tkzBGxCUWU26njd6IMx0YBpmBsthkFLwgWpe91ryC_Th6HuYzB56Cz6XZ9Qhur2Oswraqf8V77bqPjwoRkldc1YM3h4NQspOJesy2K0N3oPNStSEMsELdHm6EsP3CVJWe5csjKP2EKakGs5508mGFvLdkbQxpBRh-BuFEvWnV1V6VUwqpkqvBX_zb_xH-FRkAV4fgV3KIT7qNRGybvlvnp6p7w</recordid><startdate>19650501</startdate><enddate>19650501</enddate><creator>Maxwell, David S.</creator><creator>Kruger, Lawrence</creator><general>Rockefeller Institute Press</general><general>The Rockefeller University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>19650501</creationdate><title>The Fine Structure of Astrocytes in the Cerebral Cortex and Their Response to Focal Injury Produced by Heavy Ionizing Particles</title><author>Maxwell, David S. ; Kruger, Lawrence</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-1183db737b25ebcc7985eb437e412ca09d37af02b9eb72bfc3ef5543f1a36da53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1965</creationdate><topic>ALPHA BEAMS</topic><topic>ANIMAL CELLS</topic><topic>ASTROCYTES</topic><topic>BIOLOGY AND MEDICINE</topic><topic>BRAIN</topic><topic>Cerebral cortex</topic><topic>CONFIGURATION</topic><topic>CYTOLOGY</topic><topic>Cytoplasm</topic><topic>Electron microscopy</topic><topic>Glycogen</topic><topic>Irradiation</topic><topic>Lesions</topic><topic>MALFORMATIONS</topic><topic>NERVOUS SYSTEM</topic><topic>Neuroglia</topic><topic>Radiation dosage</topic><topic>Radiation Effects</topic><topic>RADIATION INJURIES</topic><topic>Solar fibrils</topic><topic>TISSUES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maxwell, David S.</creatorcontrib><creatorcontrib>Kruger, Lawrence</creatorcontrib><creatorcontrib>Univ. of California, Los Angeles</creatorcontrib><creatorcontrib>and Veterans Administration Hospital, Long Beach, Calif</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Cell Biology (U.S.) Formerly J. Biophys. Biochem. Cytol</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maxwell, David S.</au><au>Kruger, Lawrence</au><aucorp>Univ. of California, Los Angeles</aucorp><aucorp>and Veterans Administration Hospital, Long Beach, Calif</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Fine Structure of Astrocytes in the Cerebral Cortex and Their Response to Focal Injury Produced by Heavy Ionizing Particles</atitle><jtitle>Journal of Cell Biology (U.S.) Formerly J. Biophys. Biochem. Cytol</jtitle><addtitle>J Cell Biol</addtitle><date>1965-05-01</date><risdate>1965</risdate><volume>25</volume><issue>2</issue><spage>141</spage><epage>157</epage><pages>141-157</pages><issn>0021-9525</issn><eissn>1540-8140</eissn><abstract>Normal and reactive astrocytes in the cerebral cortex of the rat have been studied with the electron microscope following focal alpha particle irradiation. The presence of glycogen and approximately 60-A fibrils identify astrocyte cytoplasm in formalin-perfused tissue. The glycogen particles facilitate the identification of small processes and subpial and perivascular end-feet. Both protoplasmic and fibrous astrocytes contain cytoplasmic fibrils and should be distinguished on the basis of the configuration of their processes and their distribution. Acutely reactive astrocytes are characterized by a marked increase in the number of glycogen granules and mitochondria from the first day after irradiation. These cells later hypertrophy and accumulate lipid bodies and increased numbers of cytoplasmic fibrils. The glial "scar" consists of a greatly expanded volume of astrocyte cytoplasm filled with fibrils and displays no signs of astrocyte death, reversion to primitive forms, or extensive multiplication.</abstract><cop>United States</cop><pub>Rockefeller Institute Press</pub><pmid>19866658</pmid><doi>10.1083/jcb.25.2.141</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of Cell Biology (U.S.) Formerly J. Biophys. Biochem. Cytol, 1965-05, Vol.25 (2), p.141-157 |
| issn | 0021-9525 1540-8140 |
| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | ALPHA BEAMS ANIMAL CELLS ASTROCYTES BIOLOGY AND MEDICINE BRAIN Cerebral cortex CONFIGURATION CYTOLOGY Cytoplasm Electron microscopy Glycogen Irradiation Lesions MALFORMATIONS NERVOUS SYSTEM Neuroglia Radiation dosage Radiation Effects RADIATION INJURIES Solar fibrils TISSUES |
| title | The Fine Structure of Astrocytes in the Cerebral Cortex and Their Response to Focal Injury Produced by Heavy Ionizing Particles |
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