Stimulation of in vitro sumoylation by Slx5–Slx8: Evidence for a functional interaction with the SUMO pathway

The yeast genes SLX5 and SLX8 were identified based on their requirement for viability in the absence of the Sgs1 DNA helicase. Loss of these genes results in genome instability, nibbled colonies, and other phenotypes associated with defects in sumoylation. The Slx5 and Slx8 proteins form a stable c...

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Veröffentlicht in:	DNA repair 2007-11, Vol.6 (11), p.1679-1691
Hauptverfasser:	Ii, Tatsuya, Mullen, Janet R., Slagle, Christopher E., Brill, Steven J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriology Biological and medical sciences DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Fundamental and applied biological sciences. Psychology Genic rearrangement. Recombination. Transposable element Genome stability Growth, nutrition, cell differenciation Microbiology Molecular and cellular biology Molecular genetics Mutagenesis. Repair Recombination RING Finger Domains Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Sgs1 DNA helicase Signal Transduction Smt3 SUMO SUMO-1 Protein - metabolism Time Factors Ubiquitin-Protein Ligases
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