The large-conductance Ca2+-activated K+ channel is essential for innate immunity

Neutrophil leukocytes have a pivotal function in innate immunity. Dogma dictates that the lethal blow is delivered to microbes by reactive oxygen species (ROS) and halogens 1 , 2 , products of the NADPH oxidase, whose impairment causes immunodeficiency. However, recent evidence indicates that the mi...

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Veröffentlicht in:	Nature (London) 2004-02, Vol.427 (6977), p.853-858
Hauptverfasser:	Ahluwalia, Jatinder, Tinker, Andrew, Clapp, Lucie H., Duchen, Michael R., Abramov, Andrey Y., Pope, Simon, Nobles, Muriel, Segal, Anthony W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Biological and medical sciences Calcium - metabolism Electric Conductivity Eosinophils - cytology Eosinophils - drug effects Eosinophils - immunology Eosinophils - metabolism Fundamental and applied biological sciences. Psychology Fundamental immunology Humanities and Social Sciences Humans Hydrogen-Ion Concentration iberiotoxin Immunity, Innate - drug effects Immunobiology Ion Transport - drug effects Large-Conductance Calcium-Activated Potassium Channel alpha Subunits Large-Conductance Calcium-Activated Potassium Channels letter Membrane Potentials - drug effects multidisciplinary Neutrophils - cytology Neutrophils - drug effects Neutrophils - immunology Neutrophils - metabolism Organs and cells involved in the immune response Oxygen Consumption - drug effects paxilline Phagocytosis - drug effects Potassium - metabolism Potassium Channels, Calcium-Activated - antagonists & inhibitors Potassium Channels, Calcium-Activated - metabolism Rubidium Radioisotopes Science Science (multidisciplinary) Staphylococcus aureus - immunology Tetradecanoylphorbol Acetate - pharmacology Vacuoles - drug effects Vacuoles - metabolism
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