Megf10 regulates the progression of the satellite cell myogenic program

We identify here the multiple epidermal growth factor repeat transmembrane protein Megf10 as a quiescent satellite cell marker that is also expressed in skeletal myoblasts but not in differentiated myofibers. Retroviral expression of Megf10 in myoblasts results in enhanced proliferation and inhibite...

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Veröffentlicht in:	The Journal of cell biology 2007-12, Vol.179 (5), p.911-922
Hauptverfasser:	Holterman, Chet E, Le Grand, Fabien, Kuang, Shihuan, Seale, Patrick, Rudnicki, Michael A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Artificial satellites Cell Compartmentation Cell culture Cell cycle Cell Differentiation Cell growth Cell Proliferation Cellular differentiation DNA, Complementary - isolation & purification Down regulation Gene expression Hepatocytes Membrane Proteins - deficiency Membrane Proteins - metabolism Mice Muscle Development Muscle, Skeletal - cytology Muscle, Skeletal - metabolism Myoblasts Proteins Receptors, Notch - metabolism Satellite Cells, Skeletal Muscle - cytology Serum Signal Transduction Skeletal muscle Skeletal muscle satellite cells Stem cells Stem Cells - cytology Stem Cells - metabolism
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