Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K⁺ solution
Intramolecular G-quadruplexes formed by human telomere sequences are attractive anticancer targets. Recently, four-repeat human telomere sequences have been shown to form two different intramolecular (3 + 1) G-quadruplexes in K+ solution (Form 1 and Form 2). Here we report on the solution structures...
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| Veröffentlicht in: | Nucleic acids research 2007-10, Vol.35 (19), p.6517-6525 |
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| creator | Phan, Anh Tuân Kuryavyi, Vitaly Luu, Kim Ngoc Patel, Dinshaw J |
| description | Intramolecular G-quadruplexes formed by human telomere sequences are attractive anticancer targets. Recently, four-repeat human telomere sequences have been shown to form two different intramolecular (3 + 1) G-quadruplexes in K+ solution (Form 1 and Form 2). Here we report on the solution structures of both Form 1 and Form 2 adopted by natural human telomere sequences. Both structures contain the (3 + 1) G-tetrad core with one double-chain-reversal and two edgewise loops, but differ in the successive order of loop arrangements within the G-quadruplex scaffold. Our results provide the structural details at the two ends of the G-tetrad core in the context of natural sequences and information on different loop conformations. This structural information might be important for our understanding of telomere G-quadruplex structures and for anticancer drug design targeted to such scaffolds. |
| doi_str_mv | 10.1093/nar/gkm706 |
| format | Article |
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Recently, four-repeat human telomere sequences have been shown to form two different intramolecular (3 + 1) G-quadruplexes in K+ solution (Form 1 and Form 2). Here we report on the solution structures of both Form 1 and Form 2 adopted by natural human telomere sequences. Both structures contain the (3 + 1) G-tetrad core with one double-chain-reversal and two edgewise loops, but differ in the successive order of loop arrangements within the G-quadruplex scaffold. Our results provide the structural details at the two ends of the G-tetrad core in the context of natural sequences and information on different loop conformations. 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Recently, four-repeat human telomere sequences have been shown to form two different intramolecular (3 + 1) G-quadruplexes in K+ solution (Form 1 and Form 2). Here we report on the solution structures of both Form 1 and Form 2 adopted by natural human telomere sequences. Both structures contain the (3 + 1) G-tetrad core with one double-chain-reversal and two edgewise loops, but differ in the successive order of loop arrangements within the G-quadruplex scaffold. Our results provide the structural details at the two ends of the G-tetrad core in the context of natural sequences and information on different loop conformations. This structural information might be important for our understanding of telomere G-quadruplex structures and for anticancer drug design targeted to such scaffolds.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>17895279</pmid><doi>10.1093/nar/gkm706</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 2JSL 2JSM 2JSQ Base Sequence Cations DNA - chemistry G-Quadruplexes Humans Models, Molecular Nuclear Magnetic Resonance, Biomolecular PDB2JSK Potassium - chemistry Repetitive Sequences, Nucleic Acid Solutions Structural Biology Telomere - chemistry |
| title | Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K⁺ solution |
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