Comparative potencies of 3,4‐methylenedioxymethamphetamine (MDMA) analogues as inhibitors of [3H]noradrenaline and [3H]5‐HT transport in mammalian cell lines

Background and purpose: Illegal ‘ecstasy’ tablets frequently contain 3,4‐methylenedioxymethamphetamine (MDMA)‐like compounds of unknown pharmacological activity. Since monoamine transporters are one of the primary targets of MDMA action in the brain, a number of MDMA analogues have been tested for t...

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Veröffentlicht in:	British journal of pharmacology 2007-12, Vol.152 (7), p.1121-1130
Hauptverfasser:	Montgomery, T, Buon, C, Eibauer, S, Guiry, P J, Keenan, A K, McBean, G J
Format:	Artikel
Sprache:	eng
Schlagworte:	5‐hydroxytryptamine Animals Biological and medical sciences Biological Transport - drug effects Cell Line Dose-Response Relationship, Drug HEK cells Humans MDMA Medical sciences Molecular Structure N-Methyl-3,4-methylenedioxyamphetamine - analogs & derivatives N-Methyl-3,4-methylenedioxyamphetamine - chemistry N-Methyl-3,4-methylenedioxyamphetamine - pharmacology noradrenaline Norepinephrine - antagonists & inhibitors Norepinephrine - metabolism PC12 Cells Pharmacology. Drug treatments Rats Research Papers Serotonin Plasma Membrane Transport Proteins - drug effects Serotonin Plasma Membrane Transport Proteins - metabolism Stereoisomerism Structure-Activity Relationship transport
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