Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis

Immune and inflammatory systems are controlled by multiple cytokines, including ILs and INFs. These cytokines exert their biological functions through Janus tyrosine kinases and STAT transcription factors. One such cytokine, IL-6, has been proposed to contribute to the development of rheumatoid arth...

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Veröffentlicht in:	The Journal of clinical investigation 2001-12, Vol.108 (12), p.1781-1788
Hauptverfasser:	Shouda, T, Yoshida, T, Hanada, T, Wakioka, T, Oishi, M, Miyoshi, K, Komiya, S, Kosai, K, Hanakawa, Y, Hashimoto, K, Nagata, K, Yoshimura, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis, Rheumatoid - therapy Cell Division Disease Models, Animal DNA-Binding Proteins - physiology Genetic Therapy Humans Interleukin-6 - analysis Male Mice Mice, Inbred C57BL Mice, Inbred DBA Proteins - genetics Proteins - physiology Repressor Proteins RNA, Messenger - analysis Signal Transduction Stat3 protein STAT3 Transcription Factor Suppressor of Cytokine Signaling 3 Protein Suppressor of Cytokine Signaling Proteins Trans-Activators - physiology Transcription Factors
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