Interleukin-2 receptor signaling in regulatory T cell development and homeostasis

Abstract Interleukin-2 (IL2) was initially identified from supernatants of activated lymphocytes over 30 years ago. In the ensuing 15 years, the cDNAs for both IL2 and the three chains of the interleukin-2 receptor (IL2R) were cloned. Subsequently, many of the downstream biochemical pathways activat...

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Veröffentlicht in:	Immunology letters 2007-11, Vol.114 (1), p.1-8
Hauptverfasser:	Burchill, Matthew A, Yang, Jianying, Vang, Kieng B, Farrar, Michael A
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Cytokines - metabolism Development Homeostasis Humans Interleukin-2 Interleukin-2 - metabolism Receptors, Interleukin-2 - genetics Receptors, Interleukin-2 - metabolism Regulatory T cell Signal Transduction STAT5 Transcription Factor - genetics STAT5 Transcription Factor - metabolism T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - metabolism
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