Inhibition of cyclooxygenase-2 aggravates doxorubicin-mediated cardiac injury in vivo

The clinical use of doxorubicin, an anthracycline chemotherapeutic agent, is limited by cardiotoxicity, particularly when combined with herceptin, an antibody that blocks the HER2 receptor. Doxorubicin induces cyclooxygenase-2 (COX-2) activity in rat neonatal cardiomyocytes. This expression of COX-2...

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Veröffentlicht in:	The Journal of clinical investigation 2001-08, Vol.108 (4), p.585-590
Hauptverfasser:	Dowd, N P, Scully, M, Adderley, S R, Cunningham, A J, Fitzgerald, D J
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Ketoprostaglandin F1 alpha - analogs & derivatives 6-Ketoprostaglandin F1 alpha - urine Animals Apoptosis - drug effects Arachidonic Acid - pharmacology Aspirin - pharmacology Biomarkers Cardiomyopathies - chemically induced Cardiomyopathies - metabolism Cardiomyopathies - prevention & control Cyclooxygenase 1 Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - pharmacology Cyclooxygenase Inhibitors - toxicity Doxorubicin - pharmacology Doxorubicin - toxicity Enzyme Induction - drug effects Epoprostenol - biosynthesis Epoprostenol - physiology Heart - drug effects Iloprost - therapeutic use Isoenzymes - antagonists & inhibitors Isoenzymes - biosynthesis Isoenzymes - genetics Isoenzymes - physiology L-Lactate Dehydrogenase - blood Male Membrane Proteins Myocardium - metabolism Myocardium - pathology Nitrobenzenes - pharmacology Prostaglandin-Endoperoxide Synthases - biosynthesis Prostaglandin-Endoperoxide Synthases - genetics Prostaglandin-Endoperoxide Synthases - physiology Pyrazoles - pharmacology Pyrazoles - toxicity Rats Rats, Sprague-Dawley Receptors, Cytoplasmic and Nuclear - metabolism Sulfonamides - pharmacology Sulfonamides - toxicity Thromboxane B2 - blood Transcription Factors - metabolism Troponin T - blood
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