Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

Substances released by platelets during blood clotting are essential participants in events that link hemostasis and angiogenesis and ensure adequate wound healing and tissue injury repair. We assessed the participation of sphingosine 1-phosphate (Sph-1-P), a biologically active phosphorylated lipid...

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Veröffentlicht in:	The Journal of clinical investigation 2001-09, Vol.108 (5), p.689-701
Hauptverfasser:	Garcia, J G, Liu, F, Verin, A D, Birukova, A, Dechert, M A, Gerthoffer, W T, Bamberg, J R, English, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Depolymerizing Factors Actins - metabolism Animals Capillary Permeability - drug effects Cattle Cells, Cultured Cytoskeleton - metabolism Cytoskeleton - ultrastructure DNA-Binding Proteins - physiology Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Endothelium, Vascular - ultrastructure GTP-Binding Protein alpha Subunits, Gi-Go - metabolism Humans I-kappa B Proteins Immediate-Early Proteins - physiology Lysophospholipids MAP Kinase Signaling System Microfilament Proteins - metabolism Neovascularization, Physiologic NF-KappaB Inhibitor alpha p21-Activated Kinases Protein-Serine-Threonine Kinases - physiology rac GTP-Binding Proteins - physiology Receptors, Cell Surface Receptors, G-Protein-Coupled Receptors, Lysophospholipid Sphingosine - analogs & derivatives Sphingosine - pharmacology
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