Hepatocyte growth factor ameliorates acute graft-versus-host disease and promotes hematopoietic function

Acute graft-versus-host disease (GVHD) is a major complication of bone marrow transplantation (BMT) and is characterized by hematopoietic dysfunction, immunosuppression, and tissue injury in the skin, liver, and intestinal mucosa. Hepatocyte growth factor (HGF), originally identified and cloned as a...

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Veröffentlicht in:	The Journal of clinical investigation 2001-06, Vol.107 (11), p.1365-1373
Hauptverfasser:	Kuroiwa, T, Kakishita, E, Hamano, T, Kataoka, Y, Seto, Y, Iwata, N, Kaneda, Y, Matsumoto, K, Nakamura, T, Ueki, T, Fujimoto, J, Iwasaki, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Transplantation - adverse effects Disease Models, Animal Graft vs Host Disease - pathology Graft vs Host Disease - physiopathology Graft vs Host Disease - therapy Hematopoiesis, Extramedullary - physiology Hepatocyte Growth Factor - genetics Hepatocyte Growth Factor - metabolism Hepatocyte Growth Factor - therapeutic use Humans Interferon-gamma - genetics Interferon-gamma - metabolism Interleukin-12 - blood Intestines - pathology Liposomes Liver - pathology Liver - physiology Mice Mice, Inbred C57BL Muscle, Skeletal - physiology Recombinant Proteins - genetics Recombinant Proteins - metabolism Recombinant Proteins - therapeutic use Spleen - cytology Spleen - physiology Thymus Gland - cytology Transfection Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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