Expression of suppressors of cytokine signaling during liver regeneration

The cytokines TNF and IL-6 play a critical role early in liver regeneration following partial hepatectomy (PH). Since IL-6 activates signal transducers and activators of transcription (STATs), we examined whether the suppressors of cytokine signaling (SOCS) may be involved in terminating IL-6 signal...

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Veröffentlicht in:	The Journal of clinical investigation 2001-05, Vol.107 (10), p.1285-1292
Hauptverfasser:	Campbell, J S, Prichard, L, Schaper, F, Schmitz, J, Stephenson-Famy, A, Rosenfeld, M E, Argast, G M, Heinrich, P C, Fausto, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - genetics DNA-Binding Proteins - metabolism Gene Expression Regulation Hepatectomy Interleukin-6 - immunology Liver Regeneration - immunology Mice Mice, Knockout Proteins - genetics Receptors, Tumor Necrosis Factor - genetics Receptors, Tumor Necrosis Factor, Type I Repressor Proteins Signal Transduction STAT3 Transcription Factor Suppressor of Cytokine Signaling 3 Protein Suppressor of Cytokine Signaling Proteins Trans-Activators - metabolism Transcription Factors Tumor Necrosis Factor-alpha - immunology
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