Separate necdin domains bind ARNT2 and HIF1α and repress transcription

PWS is caused by the loss of expression of a set of maternally imprinted genes including NECDIN (NDN). NDN is expressed in post-mitotic neurons and plays an essential role in PWS as mouse models lacking only the Ndn gene mimic aspects of this disease. Patients haploid for SIM1 develop a PW-like synd...

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Veröffentlicht in:	Biochemical and biophysical research communications 2007-11, Vol.363 (1), p.113-118
Hauptverfasser:	Friedman, Eitan R., Fan, Chen-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Arnt2 Hif1α Hypothalamus Necdin Prader–Willi
Online-Zugang:	Volltext
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