Prototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Aβ antibody response with Alum to Quil A adjuvant switch

β-Amyloid (Aβ) peptide has been proposed to be a causal factor in Alzheimer's disease (AD). Currently being investigated, active and passive Aβ-immunotherapy significantly reduce Aβ plaque deposition, neuritic dystrophy, and astrogliosis in the brains of APP transgenic (APP/Tg) mice. Immunizati...

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Veröffentlicht in:	Vaccine 2006-03, Vol.24 (13), p.2275-2282
Hauptverfasser:	Ghochikyan, Anahit, Mkrtichyan, Mikayel, Petrushina, Irina, Movsesyan, Nina, Karapetyan, Adrine, Cribbs, David H., Agadjanyan, Michael G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease (AD) Applied microbiology Biological and medical sciences Epitope vaccine immunization Fundamental and applied biological sciences. Psychology Microbiology Th1 and Th2 adjuvants Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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