Niche-mediated control of human embryonic stem cell self-renewal and differentiation

Complexity in the spatial organization of human embryonic stem cell (hESC) cultures creates heterogeneous microenvironments (niches) that influence hESC fate. This study demonstrates that the rate and trajectory of hESC differentiation can be controlled by engineering hESC niche properties. Niche si...

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Veröffentlicht in:	The EMBO journal 2007-11, Vol.26 (22), p.4744-4755
Hauptverfasser:	Peerani, Raheem, Rao, Balaji M, Bauwens, Celine, Yin, Ting, Wood, Geoffrey A, Nagy, Andras, Kumacheva, Eugenia, Zandstra, Peter W
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone Morphogenetic Protein 2 Bone Morphogenetic Proteins - metabolism Cell Differentiation Cell Line embryonic stem cell Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Embryos Endoderm - metabolism Fibroblast Growth Factors - antagonists & inhibitors Growth Differentiation Factor 3 Humans Microenvironments micropatterning Molecular biology niche Proteins Rocks self-renewal Signal transduction Smad signaling Smad1 Protein - metabolism Stem cells Transforming Growth Factor beta - antagonists & inhibitors Transforming Growth Factor beta - metabolism
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