A Ligand-Based Approach To Identify Quantitative Structure−Activity Relationships for the Androgen Receptor

We examined the three-dimensional quantitative structure−activity relationship (QSAR) of a group of endogenous and synthetic compounds for the androgen receptor (AR) using comparative molecular field analysis (CoMFA). The goal of these studies was to identify structural features necessary for high b...

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Veröffentlicht in:	Journal of medicinal chemistry 2004-07, Vol.47 (15), p.3765-3776
Hauptverfasser:	Bohl, Casey E., Chang, Cheng, Mohler, Michael L., Chen, Jiyun, Miller, Duane D., Swaan, Peter W., Dalton, James T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anilides - chemistry Biological and medical sciences Heterocyclic Compounds, 3-Ring - chemistry Hormones. Endocrine system Ligands Medical sciences Models, Molecular Molecular Conformation Molecular Structure Nitriles Pharmacology. Drug treatments Quantitative Structure-Activity Relationship Quinolines - chemistry Receptors, Androgen - chemistry Static Electricity Steroids - chemistry Tosyl Compounds
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