Ubiquitous expression of the rtTA2S-M2 inducible system in transgenic mice driven by the human hnRNPA2B1/CBX3 CpG island

A sensitive, ubiquitously expressed tetracycline inducible system would be a valuable tool in mouse transgenesis. However, this has been difficult to obtain due to position effects observed at different chromosomal sites of transgene integration, which negatively affect expression in many tissues. T...

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Veröffentlicht in:	BMC developmental biology 2007-09, Vol.7 (1), p.108-108, Article 108
Hauptverfasser:	Katsantoni, Eleni Z, Anghelescu, Nora E, Rottier, Robbert, Moerland, Matthijs, Antoniou, Michael, de Crom, Rini, Grosveld, Frank, Strouboulis, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Northern CpG Islands - genetics DNA binding proteins Doxycycline Doxycycline - pharmacology Evaluation Gene Expression Genetic aspects Genetic engineering Genetically modified mice Green Fluorescent Proteins Growth Humans Immunohistochemistry In Situ Hybridization, Fluorescence Insulator Elements - genetics Methodology Methods Mice Mice, Transgenic Phospholipid Transfer Proteins - genetics Physiological aspects Reverse Transcriptase Polymerase Chain Reaction Tissue Distribution Transgenes
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