Hippocampal volume and subcortical white matter lesions in late life depression: comparison of early and late onset depression
Background: Reduced hippocampal volume and increased prevalence of subcortical white matter lesions are associated with both recurrent early onset depression (EOD) and late onset depression (LOD). It is not clear whether these two factors differentially affect the age of onset of first depression. T...
Gespeichert in:
| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2007-06, Vol.78 (6), p.638-640 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 640 |
|---|---|
| container_issue | 6 |
| container_start_page | 638 |
| container_title | Journal of neurology, neurosurgery and psychiatry |
| container_volume | 78 |
| creator | Janssen, Joost Hulshoff Pol, Hilleke E de Leeuw, Frank-Erik Schnack, Hugo G Lampe, Indrag K Kok, Rob M Kahn, Rene S Heeren, Thea J |
| description | Background: Reduced hippocampal volume and increased prevalence of subcortical white matter lesions are associated with both recurrent early onset depression (EOD) and late onset depression (LOD). It is not clear whether these two factors differentially affect the age of onset of first depression. Therefore, we wished to investigate the relationship between age of first depression onset and hippocampal volume, with adjustment for subcortical white matter lesions. Methods: MRI brain scans were used to compare hippocampal volumes and white matter lesions between age matched female patients (>60 years) with recurrent EOD and LOD and healthy controls. Results: When comparing the three groups and adjusting for age, the Mini-Mental State Examination score, total brain volume and total hippocampal volume were significantly smaller in patients with EOD compared with controls (5.6 vs 6.1 ml; p = 0.04). The prevalence of larger subcortical white matter lesions was higher in patients with LOD compared with patients with EOD (47% vs 8%; p = 0.002). Patients with LOD did not differ in hippocampal volume from patients with EOD or from controls. Conclusions: In late life depression, age of first depression onset may distinguish between different independent neuropathological mechanisms. A small hippocampus volume may be a neuranatomical marker of EOD depression and larger subcortical white matter lesions could be an intermediate between cerebrovascular disease and LOD. |
| doi_str_mv | 10.1136/jnnp.2006.098087 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2077968</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>19674756</sourcerecordid><originalsourceid>FETCH-LOGICAL-b623t-edf39c8b80f9199bfb030913ed0d4906af6307ef82f409863aadf47b2503fbd3</originalsourceid><addsrcrecordid>eNqFkkFv1DAQhS0EosvCnROyhOCCsoztxI45IKEVtIgVXCrUm-UkNvWSxKmdFHrht-M0q7ZwqS-WZr55mjczCD0nsCGE8bf7vh82FIBvQJZQigdoRXJeZozB2UO0AqA0Y1DAEXoS4x7mV8rH6IgISoAzWKE_J24YfK27Qbf40rdTZ7DuGxynqvZhdHUK_zp3o8GdHkcTcGui833ErsetTuHWWYMbMwQT58Q7XPukFVz0PfYWGx3aq2vFazpVmvEO_hQ9srqN5tnhX6PTTx9PtyfZ7tvx5-2HXVZxysbMNJbJuqxKsJJIWdkKGEjCTANNLoFrm8wIY0tq8zQJzrRubC4qWgCzVcPW6P0iO0xVZ5ra9GPQrRqC63S4Ul479W-md-fqh79UFISQvEwCrw8CwV9MJo6qc7E2bat746eoBBS0oLm4FySSi1wUPIEv_wP3fgp9GoIioiQ0Z5CsrxEsVB18jMHYm54JqPkE1HwCaj4BtZxAKnlx1-ttwWHnCXh1AHRM67VB97WLt1wpZi9F4rKFc3E0v2_yOvxUXDBRqK_ft0ryfHcsiy_qLPFvFr7q9ve3-RcqJNm_</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1781243062</pqid></control><display><type>article</type><title>Hippocampal volume and subcortical white matter lesions in late life depression: comparison of early and late onset depression</title><source>MEDLINE</source><source>BMJ Journals Online Archive</source><source>PubMed Central</source><source>EZB Electronic Journals Library</source><creator>Janssen, Joost ; Hulshoff Pol, Hilleke E ; de Leeuw, Frank-Erik ; Schnack, Hugo G ; Lampe, Indrag K ; Kok, Rob M ; Kahn, Rene S ; Heeren, Thea J</creator><creatorcontrib>Janssen, Joost ; Hulshoff Pol, Hilleke E ; de Leeuw, Frank-Erik ; Schnack, Hugo G ; Lampe, Indrag K ; Kok, Rob M ; Kahn, Rene S ; Heeren, Thea J</creatorcontrib><description>Background: Reduced hippocampal volume and increased prevalence of subcortical white matter lesions are associated with both recurrent early onset depression (EOD) and late onset depression (LOD). It is not clear whether these two factors differentially affect the age of onset of first depression. Therefore, we wished to investigate the relationship between age of first depression onset and hippocampal volume, with adjustment for subcortical white matter lesions. Methods: MRI brain scans were used to compare hippocampal volumes and white matter lesions between age matched female patients (>60 years) with recurrent EOD and LOD and healthy controls. Results: When comparing the three groups and adjusting for age, the Mini-Mental State Examination score, total brain volume and total hippocampal volume were significantly smaller in patients with EOD compared with controls (5.6 vs 6.1 ml; p = 0.04). The prevalence of larger subcortical white matter lesions was higher in patients with LOD compared with patients with EOD (47% vs 8%; p = 0.002). Patients with LOD did not differ in hippocampal volume from patients with EOD or from controls. Conclusions: In late life depression, age of first depression onset may distinguish between different independent neuropathological mechanisms. A small hippocampus volume may be a neuranatomical marker of EOD depression and larger subcortical white matter lesions could be an intermediate between cerebrovascular disease and LOD.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp.2006.098087</identifier><identifier>PMID: 17210630</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Age ; Age of Onset ; Biological and medical sciences ; Brain Diseases - diagnosis ; Brain Diseases - epidemiology ; Brain Diseases - pathology ; Cerebral Cortex ; Depressive Disorder, Major - diagnosis ; Depressive Disorder, Major - epidemiology ; Depressive Disorder, Major - pathology ; Diabetes ; early onset depression ; EOD ; Female ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Hippocampus ; Humans ; Hypertension ; Independent sample ; late onset depression ; LOD ; Magnetic Resonance Imaging ; Medical sciences ; Mental depression ; Middle Aged ; Mini-Mental State Examination ; MMSE ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Nervous system (semeiology, syndromes) ; Neurology ; Organ Size ; Recurrence ; Short Report ; Time Factors ; Variance analysis</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 2007-06, Vol.78 (6), p.638-640</ispartof><rights>Copyright 2007 Journal of Neurology Neurosurgery and Psychiatry</rights><rights>2007 INIST-CNRS</rights><rights>Copyright: 2007 Copyright 2007 Journal of Neurology Neurosurgery and Psychiatry</rights><rights>Copyright © 2007 BMJ Publishing Group Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b623t-edf39c8b80f9199bfb030913ed0d4906af6307ef82f409863aadf47b2503fbd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jnnp.bmj.com/content/78/6/638.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://jnnp.bmj.com/content/78/6/638.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,230,314,727,780,784,885,3196,23571,27924,27925,53791,53793,77600,77631</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18752525$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17210630$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Janssen, Joost</creatorcontrib><creatorcontrib>Hulshoff Pol, Hilleke E</creatorcontrib><creatorcontrib>de Leeuw, Frank-Erik</creatorcontrib><creatorcontrib>Schnack, Hugo G</creatorcontrib><creatorcontrib>Lampe, Indrag K</creatorcontrib><creatorcontrib>Kok, Rob M</creatorcontrib><creatorcontrib>Kahn, Rene S</creatorcontrib><creatorcontrib>Heeren, Thea J</creatorcontrib><title>Hippocampal volume and subcortical white matter lesions in late life depression: comparison of early and late onset depression</title><title>Journal of neurology, neurosurgery and psychiatry</title><addtitle>J Neurol Neurosurg Psychiatry</addtitle><description>Background: Reduced hippocampal volume and increased prevalence of subcortical white matter lesions are associated with both recurrent early onset depression (EOD) and late onset depression (LOD). It is not clear whether these two factors differentially affect the age of onset of first depression. Therefore, we wished to investigate the relationship between age of first depression onset and hippocampal volume, with adjustment for subcortical white matter lesions. Methods: MRI brain scans were used to compare hippocampal volumes and white matter lesions between age matched female patients (>60 years) with recurrent EOD and LOD and healthy controls. Results: When comparing the three groups and adjusting for age, the Mini-Mental State Examination score, total brain volume and total hippocampal volume were significantly smaller in patients with EOD compared with controls (5.6 vs 6.1 ml; p = 0.04). The prevalence of larger subcortical white matter lesions was higher in patients with LOD compared with patients with EOD (47% vs 8%; p = 0.002). Patients with LOD did not differ in hippocampal volume from patients with EOD or from controls. Conclusions: In late life depression, age of first depression onset may distinguish between different independent neuropathological mechanisms. A small hippocampus volume may be a neuranatomical marker of EOD depression and larger subcortical white matter lesions could be an intermediate between cerebrovascular disease and LOD.</description><subject>Age</subject><subject>Age of Onset</subject><subject>Biological and medical sciences</subject><subject>Brain Diseases - diagnosis</subject><subject>Brain Diseases - epidemiology</subject><subject>Brain Diseases - pathology</subject><subject>Cerebral Cortex</subject><subject>Depressive Disorder, Major - diagnosis</subject><subject>Depressive Disorder, Major - epidemiology</subject><subject>Depressive Disorder, Major - pathology</subject><subject>Diabetes</subject><subject>early onset depression</subject><subject>EOD</subject><subject>Female</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Hippocampus</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Independent sample</subject><subject>late onset depression</subject><subject>LOD</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Mini-Mental State Examination</subject><subject>MMSE</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Organ Size</subject><subject>Recurrence</subject><subject>Short Report</subject><subject>Time Factors</subject><subject>Variance analysis</subject><issn>0022-3050</issn><issn>1468-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkkFv1DAQhS0EosvCnROyhOCCsoztxI45IKEVtIgVXCrUm-UkNvWSxKmdFHrht-M0q7ZwqS-WZr55mjczCD0nsCGE8bf7vh82FIBvQJZQigdoRXJeZozB2UO0AqA0Y1DAEXoS4x7mV8rH6IgISoAzWKE_J24YfK27Qbf40rdTZ7DuGxynqvZhdHUK_zp3o8GdHkcTcGui833ErsetTuHWWYMbMwQT58Q7XPukFVz0PfYWGx3aq2vFazpVmvEO_hQ9srqN5tnhX6PTTx9PtyfZ7tvx5-2HXVZxysbMNJbJuqxKsJJIWdkKGEjCTANNLoFrm8wIY0tq8zQJzrRubC4qWgCzVcPW6P0iO0xVZ5ra9GPQrRqC63S4Ul479W-md-fqh79UFISQvEwCrw8CwV9MJo6qc7E2bat746eoBBS0oLm4FySSi1wUPIEv_wP3fgp9GoIioiQ0Z5CsrxEsVB18jMHYm54JqPkE1HwCaj4BtZxAKnlx1-ttwWHnCXh1AHRM67VB97WLt1wpZi9F4rKFc3E0v2_yOvxUXDBRqK_ft0ryfHcsiy_qLPFvFr7q9ve3-RcqJNm_</recordid><startdate>20070601</startdate><enddate>20070601</enddate><creator>Janssen, Joost</creator><creator>Hulshoff Pol, Hilleke E</creator><creator>de Leeuw, Frank-Erik</creator><creator>Schnack, Hugo G</creator><creator>Lampe, Indrag K</creator><creator>Kok, Rob M</creator><creator>Kahn, Rene S</creator><creator>Heeren, Thea J</creator><general>BMJ Publishing Group Ltd</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20070601</creationdate><title>Hippocampal volume and subcortical white matter lesions in late life depression: comparison of early and late onset depression</title><author>Janssen, Joost ; Hulshoff Pol, Hilleke E ; de Leeuw, Frank-Erik ; Schnack, Hugo G ; Lampe, Indrag K ; Kok, Rob M ; Kahn, Rene S ; Heeren, Thea J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b623t-edf39c8b80f9199bfb030913ed0d4906af6307ef82f409863aadf47b2503fbd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Age</topic><topic>Age of Onset</topic><topic>Biological and medical sciences</topic><topic>Brain Diseases - diagnosis</topic><topic>Brain Diseases - epidemiology</topic><topic>Brain Diseases - pathology</topic><topic>Cerebral Cortex</topic><topic>Depressive Disorder, Major - diagnosis</topic><topic>Depressive Disorder, Major - epidemiology</topic><topic>Depressive Disorder, Major - pathology</topic><topic>Diabetes</topic><topic>early onset depression</topic><topic>EOD</topic><topic>Female</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Hippocampus</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Independent sample</topic><topic>late onset depression</topic><topic>LOD</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Mental depression</topic><topic>Middle Aged</topic><topic>Mini-Mental State Examination</topic><topic>MMSE</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Organ Size</topic><topic>Recurrence</topic><topic>Short Report</topic><topic>Time Factors</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Janssen, Joost</creatorcontrib><creatorcontrib>Hulshoff Pol, Hilleke E</creatorcontrib><creatorcontrib>de Leeuw, Frank-Erik</creatorcontrib><creatorcontrib>Schnack, Hugo G</creatorcontrib><creatorcontrib>Lampe, Indrag K</creatorcontrib><creatorcontrib>Kok, Rob M</creatorcontrib><creatorcontrib>Kahn, Rene S</creatorcontrib><creatorcontrib>Heeren, Thea J</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Source</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest Science Journals</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Janssen, Joost</au><au>Hulshoff Pol, Hilleke E</au><au>de Leeuw, Frank-Erik</au><au>Schnack, Hugo G</au><au>Lampe, Indrag K</au><au>Kok, Rob M</au><au>Kahn, Rene S</au><au>Heeren, Thea J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hippocampal volume and subcortical white matter lesions in late life depression: comparison of early and late onset depression</atitle><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle><addtitle>J Neurol Neurosurg Psychiatry</addtitle><date>2007-06-01</date><risdate>2007</risdate><volume>78</volume><issue>6</issue><spage>638</spage><epage>640</epage><pages>638-640</pages><issn>0022-3050</issn><eissn>1468-330X</eissn><coden>JNNPAU</coden><abstract>Background: Reduced hippocampal volume and increased prevalence of subcortical white matter lesions are associated with both recurrent early onset depression (EOD) and late onset depression (LOD). It is not clear whether these two factors differentially affect the age of onset of first depression. Therefore, we wished to investigate the relationship between age of first depression onset and hippocampal volume, with adjustment for subcortical white matter lesions. Methods: MRI brain scans were used to compare hippocampal volumes and white matter lesions between age matched female patients (>60 years) with recurrent EOD and LOD and healthy controls. Results: When comparing the three groups and adjusting for age, the Mini-Mental State Examination score, total brain volume and total hippocampal volume were significantly smaller in patients with EOD compared with controls (5.6 vs 6.1 ml; p = 0.04). The prevalence of larger subcortical white matter lesions was higher in patients with LOD compared with patients with EOD (47% vs 8%; p = 0.002). Patients with LOD did not differ in hippocampal volume from patients with EOD or from controls. Conclusions: In late life depression, age of first depression onset may distinguish between different independent neuropathological mechanisms. A small hippocampus volume may be a neuranatomical marker of EOD depression and larger subcortical white matter lesions could be an intermediate between cerebrovascular disease and LOD.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>17210630</pmid><doi>10.1136/jnnp.2006.098087</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3050 |
| ispartof | Journal of neurology, neurosurgery and psychiatry, 2007-06, Vol.78 (6), p.638-640 |
| issn | 0022-3050 1468-330X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2077968 |
| source | MEDLINE; BMJ Journals Online Archive; PubMed Central; EZB Electronic Journals Library |
| subjects | Age Age of Onset Biological and medical sciences Brain Diseases - diagnosis Brain Diseases - epidemiology Brain Diseases - pathology Cerebral Cortex Depressive Disorder, Major - diagnosis Depressive Disorder, Major - epidemiology Depressive Disorder, Major - pathology Diabetes early onset depression EOD Female Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hippocampus Humans Hypertension Independent sample late onset depression LOD Magnetic Resonance Imaging Medical sciences Mental depression Middle Aged Mini-Mental State Examination MMSE Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Nervous system (semeiology, syndromes) Neurology Organ Size Recurrence Short Report Time Factors Variance analysis |
| title | Hippocampal volume and subcortical white matter lesions in late life depression: comparison of early and late onset depression |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T11%3A02%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hippocampal%20volume%20and%20subcortical%20white%20matter%20lesions%20in%20late%20life%20depression:%20comparison%20of%20early%20and%20late%20onset%20depression&rft.jtitle=Journal%20of%20neurology,%20neurosurgery%20and%20psychiatry&rft.au=Janssen,%20Joost&rft.date=2007-06-01&rft.volume=78&rft.issue=6&rft.spage=638&rft.epage=640&rft.pages=638-640&rft.issn=0022-3050&rft.eissn=1468-330X&rft.coden=JNNPAU&rft_id=info:doi/10.1136/jnnp.2006.098087&rft_dat=%3Cproquest_pubme%3E19674756%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1781243062&rft_id=info:pmid/17210630&rfr_iscdi=true |