Association between phosphodiesterase 4D gene and ischaemic stroke
Background: An association between the phosphodiesterase 4D (PDE4D) gene and risk of ischaemic stroke in an Icelandic population has been suggested by the deCODE group. Methods: A case–control study of 151 hospitalised patients with first-ever ischaemic stroke and 164 randomly selected age-matched a...
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| creator | Staton, J M Sayer, M S Hankey, G J Attia, J Thakkinstian, A Yi, Q Cole, V J Baker, R Eikelboom, J W |
| description | Background: An association between the phosphodiesterase 4D (PDE4D) gene and risk of ischaemic stroke in an Icelandic population has been suggested by the deCODE group. Methods: A case–control study of 151 hospitalised patients with first-ever ischaemic stroke and 164 randomly selected age-matched and sex-matched community controls was conducted. PDE4D genotypes for the six single-nucleotide polymorphisms (SNPs) previously reported to be independently associated with stroke were determined, common haplotypes were inferred using the expectation-maximisation algorithm, and SNP and haplotype associations with stroke were examined. A meta-analysis of published studies examining the association between PDE4D and stroke was also carried out. Results: Our study of Australian patients with stroke showed an independent association between ischaemic stroke and PDE4D SNP 89 (CC: odds ratio (OR) 5.55, 95% confidence interval (CI) 1.02 to 30.19; CA: OR 1.68, 95% CI 0.96 to 2.96; AA: OR 1 (reference)), SNP 87 (CC: OR 2.13, 95% CI 1.08 to 4.20; TC: OR 1.64, 95% CI 0.89 to 3.00; TT: OR 1 (reference)) and SNP 83 (TT: OR 2.16, 95% CI 1.08 to 4.32; TC: OR 1.37, 95% CI 0.77 to 2.43; CC: OR 1 (reference)), and between ischaemic stroke and PDE4D haplotypes at SNP 89–87–83 (A–C–C: OR 2.13, 95% CI 1.15 to 3.96; C–C–T: OR 2.25, 95% CI 1.29 to 3.92), but no association between ischaemic stroke and PDE4D SNP 56, SNP 45 or SNP 41, or with PDE4D haplotypes at SNP 56–45–41. A meta-analysis of nine case–control studies (including our current results) of 3808 stroke cases and 4377 controls confirmed a significant association between stroke and PDE SNP 87 (pooled p = 0.002), SNP 83 (0.003) and SNP 41 (0.003). However, there was statistical heterogeneity (p |
| doi_str_mv | 10.1136/jnnp.2006.092106 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2077747</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4023835961</sourcerecordid><originalsourceid>FETCH-LOGICAL-b557t-3fa1e17ea789d0057e0f109e667d0ce98110e84a87abd57ef606d764985941853</originalsourceid><addsrcrecordid>eNqFkctv1DAQxi0EokvhzglFQnBBWcZx_LpUahfoIlU8JEC9WU4y6Xq7sRc7y-O_x6usWuBSSyMfvt-M5puPkKcU5pQy8Xrt_XZeAYg56IqCuEdmtBaqZAwu75MZQFWVDDgckUcprWH_lH5IjqjQtJacz8jZaUqhdXZ0wRcNjj8RfbFdhZSrc5hGjDZhUb8prtBjYX1XuNSuLA6uLdIYwzU-Jg96u0n45PAfk6_v3n5ZLMuLj-fvF6cXZcO5HEvWW4pUopVKdwBcIvQUNAohO2hRK0oBVW2VtE2X1V6A6KSoteK6poqzY3Iyzd3umgG7Fv0Y7cZsoxts_G2CdeZfxbuVuQo_TAVSylrmAS8PA2L4vsvezJC94GZjPYZdMkJJXkHN7wSpZlRLUWXw-X_gOuyiz1cwVCpa1SAZyxRMVBtDShH7m50pmH2OZp-j2edophxzy7O_vd42HILLwIsDYFNrN320vnXpllNQyVyZKyfO5Sh_3eg2XhshmeTmw7eF-bRcXrLzs89GZ_7VxDfD-u41_wA7A8Jj</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1781240733</pqid></control><display><type>article</type><title>Association between phosphodiesterase 4D gene and ischaemic stroke</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Staton, J M ; Sayer, M S ; Hankey, G J ; Attia, J ; Thakkinstian, A ; Yi, Q ; Cole, V J ; Baker, R ; Eikelboom, J W</creator><creatorcontrib>Staton, J M ; Sayer, M S ; Hankey, G J ; Attia, J ; Thakkinstian, A ; Yi, Q ; Cole, V J ; Baker, R ; Eikelboom, J W</creatorcontrib><description>Background: An association between the phosphodiesterase 4D (PDE4D) gene and risk of ischaemic stroke in an Icelandic population has been suggested by the deCODE group. Methods: A case–control study of 151 hospitalised patients with first-ever ischaemic stroke and 164 randomly selected age-matched and sex-matched community controls was conducted. PDE4D genotypes for the six single-nucleotide polymorphisms (SNPs) previously reported to be independently associated with stroke were determined, common haplotypes were inferred using the expectation-maximisation algorithm, and SNP and haplotype associations with stroke were examined. A meta-analysis of published studies examining the association between PDE4D and stroke was also carried out. Results: Our study of Australian patients with stroke showed an independent association between ischaemic stroke and PDE4D SNP 89 (CC: odds ratio (OR) 5.55, 95% confidence interval (CI) 1.02 to 30.19; CA: OR 1.68, 95% CI 0.96 to 2.96; AA: OR 1 (reference)), SNP 87 (CC: OR 2.13, 95% CI 1.08 to 4.20; TC: OR 1.64, 95% CI 0.89 to 3.00; TT: OR 1 (reference)) and SNP 83 (TT: OR 2.16, 95% CI 1.08 to 4.32; TC: OR 1.37, 95% CI 0.77 to 2.43; CC: OR 1 (reference)), and between ischaemic stroke and PDE4D haplotypes at SNP 89–87–83 (A–C–C: OR 2.13, 95% CI 1.15 to 3.96; C–C–T: OR 2.25, 95% CI 1.29 to 3.92), but no association between ischaemic stroke and PDE4D SNP 56, SNP 45 or SNP 41, or with PDE4D haplotypes at SNP 56–45–41. A meta-analysis of nine case–control studies (including our current results) of 3808 stroke cases and 4377 controls confirmed a significant association between stroke and PDE SNP 87 (pooled p = 0.002), SNP 83 (0.003) and SNP 41 (0.003). However, there was statistical heterogeneity (p<0.1) among the studies in the direction of association for each of the individual SNPs tested. Conclusions: Our results and the pooled analyses from all the studies indicate a strong association between PDE4D and ischaemic stroke. This strengthens the evidence that PDE4D plays a key part in the pathogenesis of ischaemic stroke. Heterogeneity among the studies in the direction of association between individual SNPs and stroke suggests that the SNPs tested are in linkage disequilibrium with the causal allele(s).</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp.2006.092106</identifier><identifier>PMID: 16914755</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>3',5'-Cyclic-AMP Phosphodiesterases - genetics ; Age ; Aged ; Biological and medical sciences ; Brain Ischemia - genetics ; Case-Control Studies ; Confidence intervals ; Cyclic Nucleotide Phosphodiesterases, Type 3 ; Cyclic Nucleotide Phosphodiesterases, Type 4 ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Diabetes ; Female ; Genes ; Genetic Predisposition to Disease ; Haplotypes ; Heart attacks ; Humans ; Hypertension ; Linkage Disequilibrium ; Male ; Medical sciences ; Meta-analysis ; Middle Aged ; Neurology ; Patients ; PDE4D ; phosphodiesterase 4D ; Polymorphism, Single Nucleotide ; Short Report ; single-nucleotide polymorphism ; SNP ; Stroke ; Stroke - genetics ; Studies ; Systematic review ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 2006-09, Vol.77 (9), p.1067-1069</ispartof><rights>Copyright 2006 Journal of Neurology Neurosurgery and Psychiatry</rights><rights>2006 INIST-CNRS</rights><rights>Copyright: 2006 Copyright 2006 Journal of Neurology Neurosurgery and Psychiatry</rights><rights>Copyright © 2006 BMJ Publishing Group</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b557t-3fa1e17ea789d0057e0f109e667d0ce98110e84a87abd57ef606d764985941853</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jnnp.bmj.com/content/77/9/1067.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://jnnp.bmj.com/content/77/9/1067.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,230,314,724,777,781,882,3183,23552,27905,27906,53772,53774,77349,77380</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18027802$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16914755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Staton, J M</creatorcontrib><creatorcontrib>Sayer, M S</creatorcontrib><creatorcontrib>Hankey, G J</creatorcontrib><creatorcontrib>Attia, J</creatorcontrib><creatorcontrib>Thakkinstian, A</creatorcontrib><creatorcontrib>Yi, Q</creatorcontrib><creatorcontrib>Cole, V J</creatorcontrib><creatorcontrib>Baker, R</creatorcontrib><creatorcontrib>Eikelboom, J W</creatorcontrib><title>Association between phosphodiesterase 4D gene and ischaemic stroke</title><title>Journal of neurology, neurosurgery and psychiatry</title><addtitle>J Neurol Neurosurg Psychiatry</addtitle><description>Background: An association between the phosphodiesterase 4D (PDE4D) gene and risk of ischaemic stroke in an Icelandic population has been suggested by the deCODE group. Methods: A case–control study of 151 hospitalised patients with first-ever ischaemic stroke and 164 randomly selected age-matched and sex-matched community controls was conducted. PDE4D genotypes for the six single-nucleotide polymorphisms (SNPs) previously reported to be independently associated with stroke were determined, common haplotypes were inferred using the expectation-maximisation algorithm, and SNP and haplotype associations with stroke were examined. A meta-analysis of published studies examining the association between PDE4D and stroke was also carried out. Results: Our study of Australian patients with stroke showed an independent association between ischaemic stroke and PDE4D SNP 89 (CC: odds ratio (OR) 5.55, 95% confidence interval (CI) 1.02 to 30.19; CA: OR 1.68, 95% CI 0.96 to 2.96; AA: OR 1 (reference)), SNP 87 (CC: OR 2.13, 95% CI 1.08 to 4.20; TC: OR 1.64, 95% CI 0.89 to 3.00; TT: OR 1 (reference)) and SNP 83 (TT: OR 2.16, 95% CI 1.08 to 4.32; TC: OR 1.37, 95% CI 0.77 to 2.43; CC: OR 1 (reference)), and between ischaemic stroke and PDE4D haplotypes at SNP 89–87–83 (A–C–C: OR 2.13, 95% CI 1.15 to 3.96; C–C–T: OR 2.25, 95% CI 1.29 to 3.92), but no association between ischaemic stroke and PDE4D SNP 56, SNP 45 or SNP 41, or with PDE4D haplotypes at SNP 56–45–41. A meta-analysis of nine case–control studies (including our current results) of 3808 stroke cases and 4377 controls confirmed a significant association between stroke and PDE SNP 87 (pooled p = 0.002), SNP 83 (0.003) and SNP 41 (0.003). However, there was statistical heterogeneity (p<0.1) among the studies in the direction of association for each of the individual SNPs tested. Conclusions: Our results and the pooled analyses from all the studies indicate a strong association between PDE4D and ischaemic stroke. This strengthens the evidence that PDE4D plays a key part in the pathogenesis of ischaemic stroke. Heterogeneity among the studies in the direction of association between individual SNPs and stroke suggests that the SNPs tested are in linkage disequilibrium with the causal allele(s).</description><subject>3',5'-Cyclic-AMP Phosphodiesterases - genetics</subject><subject>Age</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Brain Ischemia - genetics</subject><subject>Case-Control Studies</subject><subject>Confidence intervals</subject><subject>Cyclic Nucleotide Phosphodiesterases, Type 3</subject><subject>Cyclic Nucleotide Phosphodiesterases, Type 4</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Diabetes</subject><subject>Female</subject><subject>Genes</subject><subject>Genetic Predisposition to Disease</subject><subject>Haplotypes</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Linkage Disequilibrium</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Patients</subject><subject>PDE4D</subject><subject>phosphodiesterase 4D</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Short Report</subject><subject>single-nucleotide polymorphism</subject><subject>SNP</subject><subject>Stroke</subject><subject>Stroke - genetics</subject><subject>Studies</subject><subject>Systematic review</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0022-3050</issn><issn>1468-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkctv1DAQxi0EokvhzglFQnBBWcZx_LpUahfoIlU8JEC9WU4y6Xq7sRc7y-O_x6usWuBSSyMfvt-M5puPkKcU5pQy8Xrt_XZeAYg56IqCuEdmtBaqZAwu75MZQFWVDDgckUcprWH_lH5IjqjQtJacz8jZaUqhdXZ0wRcNjj8RfbFdhZSrc5hGjDZhUb8prtBjYX1XuNSuLA6uLdIYwzU-Jg96u0n45PAfk6_v3n5ZLMuLj-fvF6cXZcO5HEvWW4pUopVKdwBcIvQUNAohO2hRK0oBVW2VtE2X1V6A6KSoteK6poqzY3Iyzd3umgG7Fv0Y7cZsoxts_G2CdeZfxbuVuQo_TAVSylrmAS8PA2L4vsvezJC94GZjPYZdMkJJXkHN7wSpZlRLUWXw-X_gOuyiz1cwVCpa1SAZyxRMVBtDShH7m50pmH2OZp-j2edophxzy7O_vd42HILLwIsDYFNrN320vnXpllNQyVyZKyfO5Sh_3eg2XhshmeTmw7eF-bRcXrLzs89GZ_7VxDfD-u41_wA7A8Jj</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>Staton, J M</creator><creator>Sayer, M S</creator><creator>Hankey, G J</creator><creator>Attia, J</creator><creator>Thakkinstian, A</creator><creator>Yi, Q</creator><creator>Cole, V J</creator><creator>Baker, R</creator><creator>Eikelboom, J W</creator><general>BMJ Publishing Group Ltd</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20060901</creationdate><title>Association between phosphodiesterase 4D gene and ischaemic stroke</title><author>Staton, J M ; Sayer, M S ; Hankey, G J ; Attia, J ; Thakkinstian, A ; Yi, Q ; Cole, V J ; Baker, R ; Eikelboom, J W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b557t-3fa1e17ea789d0057e0f109e667d0ce98110e84a87abd57ef606d764985941853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>3',5'-Cyclic-AMP Phosphodiesterases - genetics</topic><topic>Age</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Brain Ischemia - genetics</topic><topic>Case-Control Studies</topic><topic>Confidence intervals</topic><topic>Cyclic Nucleotide Phosphodiesterases, Type 3</topic><topic>Cyclic Nucleotide Phosphodiesterases, Type 4</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Diabetes</topic><topic>Female</topic><topic>Genes</topic><topic>Genetic Predisposition to Disease</topic><topic>Haplotypes</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Linkage Disequilibrium</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Meta-analysis</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Patients</topic><topic>PDE4D</topic><topic>phosphodiesterase 4D</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Short Report</topic><topic>single-nucleotide polymorphism</topic><topic>SNP</topic><topic>Stroke</topic><topic>Stroke - genetics</topic><topic>Studies</topic><topic>Systematic review</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Staton, J M</creatorcontrib><creatorcontrib>Sayer, M S</creatorcontrib><creatorcontrib>Hankey, G J</creatorcontrib><creatorcontrib>Attia, J</creatorcontrib><creatorcontrib>Thakkinstian, A</creatorcontrib><creatorcontrib>Yi, Q</creatorcontrib><creatorcontrib>Cole, V J</creatorcontrib><creatorcontrib>Baker, R</creatorcontrib><creatorcontrib>Eikelboom, J W</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Staton, J M</au><au>Sayer, M S</au><au>Hankey, G J</au><au>Attia, J</au><au>Thakkinstian, A</au><au>Yi, Q</au><au>Cole, V J</au><au>Baker, R</au><au>Eikelboom, J W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between phosphodiesterase 4D gene and ischaemic stroke</atitle><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle><addtitle>J Neurol Neurosurg Psychiatry</addtitle><date>2006-09-01</date><risdate>2006</risdate><volume>77</volume><issue>9</issue><spage>1067</spage><epage>1069</epage><pages>1067-1069</pages><issn>0022-3050</issn><eissn>1468-330X</eissn><coden>JNNPAU</coden><abstract>Background: An association between the phosphodiesterase 4D (PDE4D) gene and risk of ischaemic stroke in an Icelandic population has been suggested by the deCODE group. Methods: A case–control study of 151 hospitalised patients with first-ever ischaemic stroke and 164 randomly selected age-matched and sex-matched community controls was conducted. PDE4D genotypes for the six single-nucleotide polymorphisms (SNPs) previously reported to be independently associated with stroke were determined, common haplotypes were inferred using the expectation-maximisation algorithm, and SNP and haplotype associations with stroke were examined. A meta-analysis of published studies examining the association between PDE4D and stroke was also carried out. Results: Our study of Australian patients with stroke showed an independent association between ischaemic stroke and PDE4D SNP 89 (CC: odds ratio (OR) 5.55, 95% confidence interval (CI) 1.02 to 30.19; CA: OR 1.68, 95% CI 0.96 to 2.96; AA: OR 1 (reference)), SNP 87 (CC: OR 2.13, 95% CI 1.08 to 4.20; TC: OR 1.64, 95% CI 0.89 to 3.00; TT: OR 1 (reference)) and SNP 83 (TT: OR 2.16, 95% CI 1.08 to 4.32; TC: OR 1.37, 95% CI 0.77 to 2.43; CC: OR 1 (reference)), and between ischaemic stroke and PDE4D haplotypes at SNP 89–87–83 (A–C–C: OR 2.13, 95% CI 1.15 to 3.96; C–C–T: OR 2.25, 95% CI 1.29 to 3.92), but no association between ischaemic stroke and PDE4D SNP 56, SNP 45 or SNP 41, or with PDE4D haplotypes at SNP 56–45–41. A meta-analysis of nine case–control studies (including our current results) of 3808 stroke cases and 4377 controls confirmed a significant association between stroke and PDE SNP 87 (pooled p = 0.002), SNP 83 (0.003) and SNP 41 (0.003). However, there was statistical heterogeneity (p<0.1) among the studies in the direction of association for each of the individual SNPs tested. Conclusions: Our results and the pooled analyses from all the studies indicate a strong association between PDE4D and ischaemic stroke. This strengthens the evidence that PDE4D plays a key part in the pathogenesis of ischaemic stroke. Heterogeneity among the studies in the direction of association between individual SNPs and stroke suggests that the SNPs tested are in linkage disequilibrium with the causal allele(s).</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>16914755</pmid><doi>10.1136/jnnp.2006.092106</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of neurology, neurosurgery and psychiatry, 2006-09, Vol.77 (9), p.1067-1069 |
| issn | 0022-3050 1468-330X |
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| source | MEDLINE; BMJ Journals - NESLi2; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | 3',5'-Cyclic-AMP Phosphodiesterases - genetics Age Aged Biological and medical sciences Brain Ischemia - genetics Case-Control Studies Confidence intervals Cyclic Nucleotide Phosphodiesterases, Type 3 Cyclic Nucleotide Phosphodiesterases, Type 4 Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Diabetes Female Genes Genetic Predisposition to Disease Haplotypes Heart attacks Humans Hypertension Linkage Disequilibrium Male Medical sciences Meta-analysis Middle Aged Neurology Patients PDE4D phosphodiesterase 4D Polymorphism, Single Nucleotide Short Report single-nucleotide polymorphism SNP Stroke Stroke - genetics Studies Systematic review Vascular diseases and vascular malformations of the nervous system |
| title | Association between phosphodiesterase 4D gene and ischaemic stroke |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T11%3A36%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20phosphodiesterase%204D%20gene%20and%20ischaemic%20stroke&rft.jtitle=Journal%20of%20neurology,%20neurosurgery%20and%20psychiatry&rft.au=Staton,%20J%20M&rft.date=2006-09-01&rft.volume=77&rft.issue=9&rft.spage=1067&rft.epage=1069&rft.pages=1067-1069&rft.issn=0022-3050&rft.eissn=1468-330X&rft.coden=JNNPAU&rft_id=info:doi/10.1136/jnnp.2006.092106&rft_dat=%3Cproquest_pubme%3E4023835961%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1781240733&rft_id=info:pmid/16914755&rfr_iscdi=true |