Acute disseminated encephalomyelitis: a follow-up study in Taiwan

Background: Acute-disseminated encephalomyelitis (ADEM) is a demyelinating disorder of the central nervous system, whose epidemiology, clinical presentations and functional outcome are incompletely understood in Asian populations. Objective: To assess the clinical presentations, predisposing factors...

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Veröffentlicht in:	Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2007-02, Vol.78 (2), p.162-167
Hauptverfasser:	Lin, C-H, Jeng, J-S, Hsieh, S-T, Yip, P-K, Wu, R-M
Format:	Artikel
Sprache:	eng
Schlagworte:	acute disseminated encephalomyelitis ADEM Adolescent Adult Age Factors Age groups Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Apheresis Biological and medical sciences Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis central nervous system cerebrospinal fluid Child CNS Cooperation CSF diethylenetriamine penta-acetic acid Disability DTPA EAE EDSS Encephalomyelitis Encephalomyelitis, Acute Disseminated - ethnology Encephalomyelitis, Acute Disseminated - etiology Encephalomyelitis, Acute Disseminated - pathology Expanded Disability Status Scale experimental allergic encephalomyelitis Female Follow-Up Studies GCS General aspects Glasgow Coma Scale Humans Immunoglobulins Infections intravenous immunoglobulin IVIg Magnetic resonance imaging Male Medical prognosis Medical sciences Middle Aged modified Rankin’s scale MRI mRS Neurology Neuropharmacology Patients Pharmacology. Drug treatments Prognosis Risk Factors Survival analysis Taiwan - ethnology Transfusions. Complications. Transfusion reactions. Cell and gene therapy Viral infections Young adults
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Zusammenfassung:	Background: Acute-disseminated encephalomyelitis (ADEM) is a demyelinating disorder of the central nervous system, whose epidemiology, clinical presentations and functional outcome are incompletely understood in Asian populations. Objective: To assess the clinical presentations, predisposing factors and functional outcome of ADEM in Taiwan. Methods: 50 patients initially diagnosed with ADEM (male, 19; female, 31) were enrolled from 1991 to 2005. Diagnosis of ADEM or multiple sclerosis was established during a follow-up period of 2–120 months. 8 adult patients were noted to have taken the immunomodulatory drug, levamisole, within 3 months before onset of symptoms. The remaining 42 patients (male, 17; female, 25) were categorised by age as children (
ISSN:	0022-3050 1468-330X
DOI:	10.1136/jnnp.2005.084194