MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts

The interaction between osteoclasts (OCs) and multiple myeloma (MM) cells plays a key role in the pathogenesis of MM-related osteolytic bone disease (OBD). MM cells promote OC formation and, in turn, OCs enhance MM cell proliferation. Chemokines are mediators of MM effects on bone and vice versa; in...

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Veröffentlicht in:	Blood 2007-11, Vol.110 (10), p.3744-3752
Hauptverfasser:	Vallet, Sonia, Raje, Noopur, Ishitsuka, Kenji, Hideshima, Teru, Podar, Klaus, Chhetri, Shweta, Pozzi, Samantha, Breitkreutz, Iris, Kiziltepe, Tanyel, Yasui, Hiroshi, Ocio, Enrique M., Shiraishi, Norihiko, Jin, Janice, Okawa, Yutaka, Ikeda, Hiroshi, Mukherjee, Siddhartha, Vaghela, Nileshwari, Cirstea, Diana, Ladetto, Marco, Boccadoro, Mario, Anderson, Kenneth C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Cell Adhesion - drug effects Cell Communication - drug effects Cell Differentiation - drug effects Cell Fusion Cell Movement - drug effects Cell Proliferation - drug effects Cell Survival - drug effects Cells, Cultured Chemokine CCL3 - metabolism Down-Regulation - drug effects Drug Evaluation, Preclinical General aspects Genes, fos Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Medical sciences Multiple Myeloma - metabolism Multiple Myeloma - pathology Neoplasia Osteoclasts - drug effects Osteoclasts - metabolism Osteoclasts - physiology Pharmacology. Drug treatments Receptors, CCR1 - antagonists & inhibitors
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