Variability of nm23-H1/NDPK-A expression in human lymphomas and its relation to tumour aggressiveness
The nm23-H1 gene is a putative metastasis-suppressor gene encoding a 17 kDa protein with nucleoside diphosphate kinase activity. Expression of nm23-H1/NDPK-A correlates inversely with the metastasising potential of some human tumours and experimental animal cells. No nm23 expression studies exist fo...
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| Veröffentlicht in: | British journal of cancer 1996-12, Vol.74 (11), p.1693-1698 |
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| creator | Aryee, DNT Simonitsch, I Mosberger, I Kos, K Mann, G Schlögl, E Pötschger, U Gadner, H Radaszkiewicz, T Kovar, H |
| description | The nm23-H1 gene is a putative metastasis-suppressor gene encoding a 17 kDa protein with nucleoside diphosphate kinase activity. Expression of nm23-H1/NDPK-A correlates inversely with the metastasising potential of some human tumours and experimental animal cells. No nm23 expression studies exist for human malignant lymphomas so far. In this study, we examined nm23-H1 expression by Northern and immunohistochemical analysis in 106 primary lymphoma samples from patients with Hodgkin's disease (HD) (n = 15), high-grade non-Hodgkin's lymphoma (NHL) from different lineages (n = 71) and low-grade NHL (n = 20). Both inter- and intra-subtype variations in nm23-H1/NDPK-A expression levels were demonstrated by all disease subtypes. Besides this heterogeneity, a general trend towards highly malignant samples expressing higher nm23-H1/NDPK-A, levels than the low-grade lymphomas was observed. Both adult and childhood HD and high-grade NHL samples exhibited significantly higher NDPK-A expression than the low-grade NHL found only in adults. High nm23-H1/NDPK-A levels in lymphoma samples did not always reflect proliferative activity of tumour cells as monitored by Ki-67 antigen staining. Fifty samples were further investigated for possible mutations in the nm23-H1 coding sequence by means of reverse transcriptase-polymerase chain reaction (RT-PCR) and single-strand conformation polymorphism (SSCP) analysis. No mutation was found by this screening. Our results suggest a role for nm23-H1 expression in the disease aggressiveness of lymphomas. |
| doi_str_mv | 10.1038/bjc.1996.616 |
| format | Article |
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Expression of nm23-H1/NDPK-A correlates inversely with the metastasising potential of some human tumours and experimental animal cells. No nm23 expression studies exist for human malignant lymphomas so far. In this study, we examined nm23-H1 expression by Northern and immunohistochemical analysis in 106 primary lymphoma samples from patients with Hodgkin's disease (HD) (n = 15), high-grade non-Hodgkin's lymphoma (NHL) from different lineages (n = 71) and low-grade NHL (n = 20). Both inter- and intra-subtype variations in nm23-H1/NDPK-A expression levels were demonstrated by all disease subtypes. Besides this heterogeneity, a general trend towards highly malignant samples expressing higher nm23-H1/NDPK-A, levels than the low-grade lymphomas was observed. Both adult and childhood HD and high-grade NHL samples exhibited significantly higher NDPK-A expression than the low-grade NHL found only in adults. High nm23-H1/NDPK-A levels in lymphoma samples did not always reflect proliferative activity of tumour cells as monitored by Ki-67 antigen staining. Fifty samples were further investigated for possible mutations in the nm23-H1 coding sequence by means of reverse transcriptase-polymerase chain reaction (RT-PCR) and single-strand conformation polymorphism (SSCP) analysis. No mutation was found by this screening. Our results suggest a role for nm23-H1 expression in the disease aggressiveness of lymphomas.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.1996.616</identifier><identifier>PMID: 8956779</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibodies, Neoplasm - immunology ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Child ; Child, Preschool ; DNA Mutational Analysis ; Drug Resistance ; Epidemiology ; experimental-oncology ; Female ; Genes, Tumor Suppressor ; Hematologic and hematopoietic diseases ; Hodgkin Disease - genetics ; Hodgkin Disease - immunology ; Hodgkin Disease - metabolism ; Hodgkin Disease - pathology ; Humans ; Infant ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma, Non-Hodgkin - genetics ; Lymphoma, Non-Hodgkin - immunology ; Lymphoma, Non-Hodgkin - metabolism ; Lymphoma, Non-Hodgkin - pathology ; Male ; Medical sciences ; Middle Aged ; Molecular Medicine ; Monomeric GTP-Binding Proteins ; Neoplasm Proteins - genetics ; Neoplasm Proteins - metabolism ; NM23 Nucleoside Diphosphate Kinases ; Nucleoside-Diphosphate Kinase ; Oncology ; Polymerase Chain Reaction - methods ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Transcription Factors - genetics ; Transcription Factors - metabolism</subject><ispartof>British journal of cancer, 1996-12, Vol.74 (11), p.1693-1698</ispartof><rights>Cancer Research Campaign 1996</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-c391c074283aa7f1b527544453f32268ef3a298ba5dc0f869f2b86a7ec50706b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077220/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077220/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2503352$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8956779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aryee, DNT</creatorcontrib><creatorcontrib>Simonitsch, I</creatorcontrib><creatorcontrib>Mosberger, I</creatorcontrib><creatorcontrib>Kos, K</creatorcontrib><creatorcontrib>Mann, G</creatorcontrib><creatorcontrib>Schlögl, E</creatorcontrib><creatorcontrib>Pötschger, U</creatorcontrib><creatorcontrib>Gadner, H</creatorcontrib><creatorcontrib>Radaszkiewicz, T</creatorcontrib><creatorcontrib>Kovar, H</creatorcontrib><title>Variability of nm23-H1/NDPK-A expression in human lymphomas and its relation to tumour aggressiveness</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>The nm23-H1 gene is a putative metastasis-suppressor gene encoding a 17 kDa protein with nucleoside diphosphate kinase activity. Expression of nm23-H1/NDPK-A correlates inversely with the metastasising potential of some human tumours and experimental animal cells. No nm23 expression studies exist for human malignant lymphomas so far. In this study, we examined nm23-H1 expression by Northern and immunohistochemical analysis in 106 primary lymphoma samples from patients with Hodgkin's disease (HD) (n = 15), high-grade non-Hodgkin's lymphoma (NHL) from different lineages (n = 71) and low-grade NHL (n = 20). Both inter- and intra-subtype variations in nm23-H1/NDPK-A expression levels were demonstrated by all disease subtypes. Besides this heterogeneity, a general trend towards highly malignant samples expressing higher nm23-H1/NDPK-A, levels than the low-grade lymphomas was observed. Both adult and childhood HD and high-grade NHL samples exhibited significantly higher NDPK-A expression than the low-grade NHL found only in adults. High nm23-H1/NDPK-A levels in lymphoma samples did not always reflect proliferative activity of tumour cells as monitored by Ki-67 antigen staining. Fifty samples were further investigated for possible mutations in the nm23-H1 coding sequence by means of reverse transcriptase-polymerase chain reaction (RT-PCR) and single-strand conformation polymorphism (SSCP) analysis. No mutation was found by this screening. Our results suggest a role for nm23-H1 expression in the disease aggressiveness of lymphomas.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibodies, Neoplasm - immunology</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>DNA Mutational Analysis</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>experimental-oncology</subject><subject>Female</subject><subject>Genes, Tumor Suppressor</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hodgkin Disease - genetics</subject><subject>Hodgkin Disease - immunology</subject><subject>Hodgkin Disease - metabolism</subject><subject>Hodgkin Disease - pathology</subject><subject>Humans</subject><subject>Infant</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma, Non-Hodgkin - genetics</subject><subject>Lymphoma, Non-Hodgkin - immunology</subject><subject>Lymphoma, Non-Hodgkin - metabolism</subject><subject>Lymphoma, Non-Hodgkin - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Monomeric GTP-Binding Proteins</subject><subject>Neoplasm Proteins - genetics</subject><subject>Neoplasm Proteins - metabolism</subject><subject>NM23 Nucleoside Diphosphate Kinases</subject><subject>Nucleoside-Diphosphate Kinase</subject><subject>Oncology</subject><subject>Polymerase Chain Reaction - methods</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvEzEUhS1EVUJgxxbJC8SKSf0YvzZIVXm0agUsgK11x_EkjmY8qT1TkX-PQ6KoSEisrqzz-fhcH4ReUbKghOuLZuMW1Bi5kFQ-QTMqOKuoZuopmhFCVEUMI8_Q85w35WiIVufoXBshlTIz5H9CCtCELow7PLQ49oxX1_Tiy4dvt9Ul9r-2yecchohDxOuph4i7Xb9dDz1kDHGJw5hx8h2Me2Yc8Dj1w5QwrFZ_Lj74WMYLdNZCl_3L45yjH58-fr-6ru6-fr65uryrXK3MWDluqCOqZpoDqJY2gilR17XgLWdMat9yYEY3IJaOtFqaljVagvJOEEVkw-fo_cF3OzW9XzofxwSd3abQQ9rZAYL9W4lhbVfDg2VEKcZIMXh7NEjD_eTzaPuQne86iH6YslVa0rqk_C9IhZZMluRz9O4AujTknHx7SkOJ3fdnS392358t_RX89eMNTvCxsKK_OeqQHXRtguhCPmFMEM4FK1h1wHJR4sonuymtxPL3_372NzH-sqo</recordid><startdate>19961201</startdate><enddate>19961201</enddate><creator>Aryee, DNT</creator><creator>Simonitsch, I</creator><creator>Mosberger, I</creator><creator>Kos, K</creator><creator>Mann, G</creator><creator>Schlögl, E</creator><creator>Pötschger, U</creator><creator>Gadner, H</creator><creator>Radaszkiewicz, T</creator><creator>Kovar, H</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19961201</creationdate><title>Variability of nm23-H1/NDPK-A expression in human lymphomas and its relation to tumour aggressiveness</title><author>Aryee, DNT ; Simonitsch, I ; Mosberger, I ; Kos, K ; Mann, G ; Schlögl, E ; Pötschger, U ; Gadner, H ; Radaszkiewicz, T ; Kovar, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-c391c074283aa7f1b527544453f32268ef3a298ba5dc0f869f2b86a7ec50706b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antibodies, Neoplasm - immunology</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>DNA Mutational Analysis</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>experimental-oncology</topic><topic>Female</topic><topic>Genes, Tumor Suppressor</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hodgkin Disease - genetics</topic><topic>Hodgkin Disease - immunology</topic><topic>Hodgkin Disease - metabolism</topic><topic>Hodgkin Disease - pathology</topic><topic>Humans</topic><topic>Infant</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphoma, Non-Hodgkin - genetics</topic><topic>Lymphoma, Non-Hodgkin - immunology</topic><topic>Lymphoma, Non-Hodgkin - metabolism</topic><topic>Lymphoma, Non-Hodgkin - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Monomeric GTP-Binding Proteins</topic><topic>Neoplasm Proteins - genetics</topic><topic>Neoplasm Proteins - metabolism</topic><topic>NM23 Nucleoside Diphosphate Kinases</topic><topic>Nucleoside-Diphosphate Kinase</topic><topic>Oncology</topic><topic>Polymerase Chain Reaction - methods</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aryee, DNT</creatorcontrib><creatorcontrib>Simonitsch, I</creatorcontrib><creatorcontrib>Mosberger, I</creatorcontrib><creatorcontrib>Kos, K</creatorcontrib><creatorcontrib>Mann, G</creatorcontrib><creatorcontrib>Schlögl, E</creatorcontrib><creatorcontrib>Pötschger, U</creatorcontrib><creatorcontrib>Gadner, H</creatorcontrib><creatorcontrib>Radaszkiewicz, T</creatorcontrib><creatorcontrib>Kovar, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aryee, DNT</au><au>Simonitsch, I</au><au>Mosberger, I</au><au>Kos, K</au><au>Mann, G</au><au>Schlögl, E</au><au>Pötschger, U</au><au>Gadner, H</au><au>Radaszkiewicz, T</au><au>Kovar, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Variability of nm23-H1/NDPK-A expression in human lymphomas and its relation to tumour aggressiveness</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>1996-12-01</date><risdate>1996</risdate><volume>74</volume><issue>11</issue><spage>1693</spage><epage>1698</epage><pages>1693-1698</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>The nm23-H1 gene is a putative metastasis-suppressor gene encoding a 17 kDa protein with nucleoside diphosphate kinase activity. Expression of nm23-H1/NDPK-A correlates inversely with the metastasising potential of some human tumours and experimental animal cells. No nm23 expression studies exist for human malignant lymphomas so far. In this study, we examined nm23-H1 expression by Northern and immunohistochemical analysis in 106 primary lymphoma samples from patients with Hodgkin's disease (HD) (n = 15), high-grade non-Hodgkin's lymphoma (NHL) from different lineages (n = 71) and low-grade NHL (n = 20). Both inter- and intra-subtype variations in nm23-H1/NDPK-A expression levels were demonstrated by all disease subtypes. Besides this heterogeneity, a general trend towards highly malignant samples expressing higher nm23-H1/NDPK-A, levels than the low-grade lymphomas was observed. Both adult and childhood HD and high-grade NHL samples exhibited significantly higher NDPK-A expression than the low-grade NHL found only in adults. High nm23-H1/NDPK-A levels in lymphoma samples did not always reflect proliferative activity of tumour cells as monitored by Ki-67 antigen staining. Fifty samples were further investigated for possible mutations in the nm23-H1 coding sequence by means of reverse transcriptase-polymerase chain reaction (RT-PCR) and single-strand conformation polymorphism (SSCP) analysis. No mutation was found by this screening. Our results suggest a role for nm23-H1 expression in the disease aggressiveness of lymphomas.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>8956779</pmid><doi>10.1038/bjc.1996.616</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Antibodies, Neoplasm - immunology Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Child Child, Preschool DNA Mutational Analysis Drug Resistance Epidemiology experimental-oncology Female Genes, Tumor Suppressor Hematologic and hematopoietic diseases Hodgkin Disease - genetics Hodgkin Disease - immunology Hodgkin Disease - metabolism Hodgkin Disease - pathology Humans Infant Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, Non-Hodgkin - genetics Lymphoma, Non-Hodgkin - immunology Lymphoma, Non-Hodgkin - metabolism Lymphoma, Non-Hodgkin - pathology Male Medical sciences Middle Aged Molecular Medicine Monomeric GTP-Binding Proteins Neoplasm Proteins - genetics Neoplasm Proteins - metabolism NM23 Nucleoside Diphosphate Kinases Nucleoside-Diphosphate Kinase Oncology Polymerase Chain Reaction - methods RNA, Messenger - genetics RNA, Messenger - metabolism Transcription Factors - genetics Transcription Factors - metabolism |
| title | Variability of nm23-H1/NDPK-A expression in human lymphomas and its relation to tumour aggressiveness |
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