Confocal microscopy of idarubicin localisation in sensitive and multidrug-resistant bladder cancer cell lines

Confocal microscopy of idarubicin localisation in sensitive and multidrug-resistant bladder cancer cell lines

Idarubicin is a highly lipophilic anthracycline and appears effective against tumours resistant to conventional anthracyclines. Confocal microscopy demonstrates predominantly cytoplasmic idarubicin accumulation. This distribution is unaltered by resistance status or the resistance reversing agent ve...

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Veröffentlicht in:British journal of cancer 1996-09, Vol.74 (6), p.906-909
Hauptverfasser: Duffy, PM, Hayes, MC, Cooper, A, Smart, CJ
Format: Artikel
Sprache:eng
Schlagworte:
Antibiotics, Antineoplastic - pharmacokinetics
Antineoplastic agents
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cell Nucleus - metabolism
Drug Resistance
Drug Resistance, Multiple
Epidemiology
experimental-oncology
General aspects
Humans
Idarubicin - pharmacokinetics
Medical sciences
Microscopy, Confocal
Molecular Medicine
Oncology
Pharmacology. Drug treatments
Tumor Cells, Cultured
Urinary Bladder Neoplasms - metabolism
Verapamil - pharmacology
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Zusammenfassung:Idarubicin is a highly lipophilic anthracycline and appears effective against tumours resistant to conventional anthracyclines. Confocal microscopy demonstrates predominantly cytoplasmic idarubicin accumulation. This distribution is unaltered by resistance status or the resistance reversing agent verapamil. Our results contrast with studies on conventional anthracyclines and suggest that nuclear accumulation may not be a prerequisite for anthracycline cytotoxicity.
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.1996.455