Schedule-dependent interaction between paclitaxel and 5-fluorouracil in human carcinoma cell lines in vitro

We assessed the cytotoxic interaction between paclitaxel and 5-fluorouracil administered at various schedules against four human carcinoma cell lines, A549, MCF7, PA1 and WiDr. The cells were exposed simultaneously to paclitaxel and to 5-fluorouracil for 24 h or sequentially to one drug for 24 h fol...

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Veröffentlicht in:	British journal of cancer 1996-09, Vol.74 (5), p.704-710
Hauptverfasser:	Kano, Y, Akutsu, M, Tsunoda, S, Ando, J, Matsui, J, Suzuki, K, Ikeda, T, Inoue, Y, Adachi, KI
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - adverse effects Antineoplastic agents Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - adverse effects Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Biomedical and Life Sciences Biomedicine Breast Neoplasms - drug therapy Cancer Research Cell Death - drug effects Colonic Neoplasms - drug therapy Dose-Response Relationship, Drug Drug Administration Schedule Drug Interactions Drug Resistance Epidemiology experimental-oncology Female Fluorouracil - administration & dosage Fluorouracil - adverse effects General aspects Humans Lung Neoplasms - drug therapy Medical sciences Molecular Medicine Oncology Ovarian Neoplasms - drug therapy Paclitaxel - administration & dosage Paclitaxel - adverse effects Pharmacology. Drug treatments Tumor Cells, Cultured - drug effects
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