Nicotinamide pharmacokinetics in humans: effect of gastric acid inhibition, comparison of rectal vs oral administration and the use of saliva for drug monitoring

The effect of inhibiting gastric acid secretion on nicotinamide pharmacokinetics was studied in five volunteers with the intent of reducing the large variations observed previously in the time to and magnitude of peak plasma concentrations. Plasma levels were determined using a standard high-perform...

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Veröffentlicht in:	British journal of cancer 1996-07, Vol.74 (1), p.16-21
Hauptverfasser:	STRATFORD, M. R. L, DENNIS, M. F, HOSKIN, P, PHILLIPS, H, HODGKISS, R. J, ROJAS, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Administration, Oral Administration, Rectal Antacids - pharmacology Biological and medical sciences Drug Interactions Female Gastric Acid - metabolism Humans Male Medical sciences Niacinamide - blood Niacinamide - pharmacokinetics Omeprazole - pharmacology Radiation therapy and radiosensitizing agent Radiation-Sensitizing Agents - metabolism Radiation-Sensitizing Agents - pharmacokinetics Saliva - chemistry Saliva - metabolism Suppositories Treatment with physical agents Treatment. General aspects Tumors
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