Discovery and Therapeutic Promise of Selective Androgen Receptor Modulators
Androgens are essential for male development and the maintenance of male secondary characteristics, such as bone mass, muscle mass, body composition, and spermatogenesis. The main disadvantages of steroidal androgens are their undesirable physicochemical and pharmacokinetic properties. The recent di...
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| Veröffentlicht in: | Molecular interventions 2005-06, Vol.5 (3), p.173-188 |
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| container_title | Molecular interventions |
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| creator | Chen, Jiyun Kim, Juhyun Dalton, James T |
| description | Androgens are essential for male development and the maintenance of male secondary characteristics, such as bone mass, muscle
mass, body composition, and spermatogenesis. The main disadvantages of steroidal androgens are their undesirable physicochemical
and pharmacokinetic properties. The recent discovery of nonsteroidal selective androgen receptor modulators (SARMs) provides
a promising alternative for testosterone replacement therapies with advantages including oral bioavailability, flexibility
of structural modification, androgen receptor specificity, tissue selectivity, and the lack of steroid-related side effects. |
| doi_str_mv | 10.1124/mi.5.3.7 |
| format | Article |
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mass, body composition, and spermatogenesis. The main disadvantages of steroidal androgens are their undesirable physicochemical
and pharmacokinetic properties. The recent discovery of nonsteroidal selective androgen receptor modulators (SARMs) provides
a promising alternative for testosterone replacement therapies with advantages including oral bioavailability, flexibility
of structural modification, androgen receptor specificity, tissue selectivity, and the lack of steroid-related side effects.</description><identifier>ISSN: 1534-0384</identifier><identifier>EISSN: 1543-2548</identifier><identifier>DOI: 10.1124/mi.5.3.7</identifier><identifier>PMID: 15994457</identifier><language>eng</language><publisher>United States: American Society for Pharmacology and Experimental Therapeutics</publisher><subject>Androgen Receptor Antagonists ; Androgens - metabolism ; Animals ; Drug Design ; Hormone Antagonists - chemistry ; Hormone Antagonists - metabolism ; Hormone Antagonists - pharmacokinetics ; Hormone Antagonists - pharmacology ; Humans ; Receptors, Androgen - metabolism ; Structure-Activity Relationship</subject><ispartof>Molecular interventions, 2005-06, Vol.5 (3), p.173-188</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-203e236fa61d11473358015ccca3e4244eb2197746933e5a25d2f5805ac231ad3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15994457$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Jiyun</creatorcontrib><creatorcontrib>Kim, Juhyun</creatorcontrib><creatorcontrib>Dalton, James T</creatorcontrib><title>Discovery and Therapeutic Promise of Selective Androgen Receptor Modulators</title><title>Molecular interventions</title><addtitle>Mol Interv</addtitle><description>Androgens are essential for male development and the maintenance of male secondary characteristics, such as bone mass, muscle
mass, body composition, and spermatogenesis. The main disadvantages of steroidal androgens are their undesirable physicochemical
and pharmacokinetic properties. The recent discovery of nonsteroidal selective androgen receptor modulators (SARMs) provides
a promising alternative for testosterone replacement therapies with advantages including oral bioavailability, flexibility
of structural modification, androgen receptor specificity, tissue selectivity, and the lack of steroid-related side effects.</description><subject>Androgen Receptor Antagonists</subject><subject>Androgens - metabolism</subject><subject>Animals</subject><subject>Drug Design</subject><subject>Hormone Antagonists - chemistry</subject><subject>Hormone Antagonists - metabolism</subject><subject>Hormone Antagonists - pharmacokinetics</subject><subject>Hormone Antagonists - pharmacology</subject><subject>Humans</subject><subject>Receptors, Androgen - metabolism</subject><subject>Structure-Activity Relationship</subject><issn>1534-0384</issn><issn>1543-2548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1Lw0AQhhdRbK2Cv0By8OAlMfuVTS9CqZ9YUbSel-1mkqwk2bCbVvrvTW3x4zQvzDPPMIPQKY4jjAm7rE3EIxqJPTTEnNGQcJbubzJlYUxTNkBH3n_EMU4Fp4dogPl4zBgXQ_R4bby2K3DrQDVZMC_BqRaWndHBi7O18RDYPHiDCnRnVhBMmszZAprgFTS0nXXBk82WleqTP0YHuao8nOzqCL3f3syn9-Hs-e5hOpmFmiW8C0lMgdAkVwnOMGaCUp7GmGutFQVGGIMFwWMhWDKmFLgiPCN5j3ClCcUqoyN0tfW2y0UNmYamc6qSrTO1cmtplZH_O40pZWFXksSCpEL0goutQDvrvYP8ZxbHcvNQWRvJJZUb9Ozvrl9w98EeON8CpSnKT-NAtqVytdK2ssX624L7E78A_6R-wg</recordid><startdate>20050601</startdate><enddate>20050601</enddate><creator>Chen, Jiyun</creator><creator>Kim, Juhyun</creator><creator>Dalton, James T</creator><general>American Society for Pharmacology and Experimental Therapeutics</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20050601</creationdate><title>Discovery and Therapeutic Promise of Selective Androgen Receptor Modulators</title><author>Chen, Jiyun ; Kim, Juhyun ; Dalton, James T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-203e236fa61d11473358015ccca3e4244eb2197746933e5a25d2f5805ac231ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Androgen Receptor Antagonists</topic><topic>Androgens - metabolism</topic><topic>Animals</topic><topic>Drug Design</topic><topic>Hormone Antagonists - chemistry</topic><topic>Hormone Antagonists - metabolism</topic><topic>Hormone Antagonists - pharmacokinetics</topic><topic>Hormone Antagonists - pharmacology</topic><topic>Humans</topic><topic>Receptors, Androgen - metabolism</topic><topic>Structure-Activity Relationship</topic><toplevel>online_resources</toplevel><creatorcontrib>Chen, Jiyun</creatorcontrib><creatorcontrib>Kim, Juhyun</creatorcontrib><creatorcontrib>Dalton, James T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular interventions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Jiyun</au><au>Kim, Juhyun</au><au>Dalton, James T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Discovery and Therapeutic Promise of Selective Androgen Receptor Modulators</atitle><jtitle>Molecular interventions</jtitle><addtitle>Mol Interv</addtitle><date>2005-06-01</date><risdate>2005</risdate><volume>5</volume><issue>3</issue><spage>173</spage><epage>188</epage><pages>173-188</pages><issn>1534-0384</issn><eissn>1543-2548</eissn><abstract>Androgens are essential for male development and the maintenance of male secondary characteristics, such as bone mass, muscle
mass, body composition, and spermatogenesis. The main disadvantages of steroidal androgens are their undesirable physicochemical
and pharmacokinetic properties. The recent discovery of nonsteroidal selective androgen receptor modulators (SARMs) provides
a promising alternative for testosterone replacement therapies with advantages including oral bioavailability, flexibility
of structural modification, androgen receptor specificity, tissue selectivity, and the lack of steroid-related side effects.</abstract><cop>United States</cop><pub>American Society for Pharmacology and Experimental Therapeutics</pub><pmid>15994457</pmid><doi>10.1124/mi.5.3.7</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Molecular interventions, 2005-06, Vol.5 (3), p.173-188 |
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| language | eng |
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| source | MEDLINE; CLOCKSS; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Androgen Receptor Antagonists Androgens - metabolism Animals Drug Design Hormone Antagonists - chemistry Hormone Antagonists - metabolism Hormone Antagonists - pharmacokinetics Hormone Antagonists - pharmacology Humans Receptors, Androgen - metabolism Structure-Activity Relationship |
| title | Discovery and Therapeutic Promise of Selective Androgen Receptor Modulators |
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