The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors

Migration is a basic feature of many cell types in a wide range of species 1 . Since the 1800s, cell migration has been proposed to occur in the nervous and immune systems 2 , 3 , and distinct molecular cues for mammalian neurons and leukocytes have been identified. Here we report that Slit, a secre...

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Veröffentlicht in:	Nature (London) 2001-04, Vol.410 (6831), p.948-952
Hauptverfasser:	Wu, Jane Y., Feng, Lili, Park, Hwan-Tae, Havlioglu, Necat, Wen, Leng, Tang, Hao, Bacon, Kevin B., Jiang, Zhi-hong, Zhang, Xiao-chun, Rao, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line Cell physiology Cells Cellular biology Chemokine CXCL12 Chemokines, CXC - metabolism Chemokines, CXC - pharmacology Chemotactic Factors - pharmacology Chemotactic Factors - physiology Chemotaxis, Leukocyte - drug effects Fundamental and applied biological sciences. Psychology Gene Expression Glycoproteins HL-60 Cells Humanities and Social Sciences Humans letter Mammals Metazoa Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - metabolism Molecular and cellular biology Motility and taxis multidisciplinary N-Formylmethionine Leucyl-Phenylalanine - pharmacology Nerve Tissue Proteins - genetics Nerve Tissue Proteins - pharmacology Nerve Tissue Proteins - physiology Neurons Neutrophils - drug effects Neutrophils - metabolism Neutrophils - physiology Proteins Rats Receptors, CXCR4 - physiology Receptors, Immunologic - physiology Respiratory Burst - drug effects Robo protein Roundabout Proteins Science Science (multidisciplinary) Slit protein
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