Genetic Alteration of Endothelial Heparan Sulfate Selectively Inhibits Tumor Angiogenesis

To examine the role of endothelial heparan sulfate during angiogenesis, we generated mice bearing an endothelial-tarqceted deletion in the biosyn- thetic enzyme N-acetylglucosamine N-deacetylase/ N-sulfotransferase 1 (Ndstl). Physiological angiogenesis during cutaneous wound repair was unaffected, a...

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Veröffentlicht in:	The Journal of cell biology 2007-05, Vol.177 (3), p.539-549
Hauptverfasser:	Fuster, Mark M., Wang, Lianchun, Castagnola, Janice, Sikora, Lyudmila, Reddi, Krisanavane, Lee, Phillip H. A., Radek, Katherine A., Schuksz, Manuela, Bishop, Joseph R., Gallo, Richard L., Sriramarao, P., Esko, Jeffrey D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Antibodies Apoptosis - drug effects Apoptosis - genetics Biochemistry Cardiovascular system Cell growth Cell Line, Tumor Endothelial cells Endothelial growth factors Endothelium, Vascular - enzymology Endothelium, Vascular - pathology Extracellular Signal-Regulated MAP Kinases - metabolism Fibroblast Growth Factor 2 - pharmacology Glucose Heparan sulfate Heparin Heparitin Sulfate - metabolism Mice Mice, Mutant Strains Neoplasm Proteins - deficiency Neoplasm Proteins - metabolism Neoplasms, Experimental - enzymology Neoplasms, Experimental - genetics Neoplasms, Experimental - pathology Neovascularization, Pathologic - enzymology Neovascularization, Pathologic - genetics Neovascularization, Pathologic - pathology Organ Specificity - genetics Phosphorylation - drug effects Rodents Sulfates Sulfotransferases - deficiency Sulfotransferases - metabolism Tumors Vascular Endothelial Growth Factor A - pharmacology
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