Inheritance of cortical ER in yeast is required for normal septin organization
How cells monitor the distribution of organelles is largely unknown. In budding yeast, the largest subdomain of the endoplasmic reticulum (ER) is a network of cortical ER (cER) that adheres to the plasma membrane. Delivery of cER from mother cells to buds, which is termed cER inheritance, occurs as...
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| Veröffentlicht in: | The Journal of cell biology 2007-11, Vol.179 (3), p.467-483 |
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| container_title | The Journal of cell biology |
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| creator | Loewen, Christopher J.R Young, Barry P Tavassoli, Shabnam Levine, Timothy P |
| description | How cells monitor the distribution of organelles is largely unknown. In budding yeast, the largest subdomain of the endoplasmic reticulum (ER) is a network of cortical ER (cER) that adheres to the plasma membrane. Delivery of cER from mother cells to buds, which is termed cER inheritance, occurs as an orderly process early in budding. We find that cER inheritance is defective in cells lacking Scs2, a yeast homologue of the integral ER membrane protein VAP (vesicle-associated membrane protein-associated protein) conserved in all eukaryotes. Scs2 and human VAP both target yeast bud tips, suggesting a conserved action of VAP in attaching ER to sites of polarized growth. In addition, the loss of either Scs2 or Ice2 (another protein involved in cER inheritance) perturbs septin assembly at the bud neck. This perturbation leads to a delay in the transition through G2, activating the Saccharomyces wee1 kinase (Swe1) and the morphogenesis checkpoint. Thus, we identify a mechanism involved in sensing the distribution of ER. |
| doi_str_mv | 10.1083/jcb.200708205 |
| format | Article |
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In budding yeast, the largest subdomain of the endoplasmic reticulum (ER) is a network of cortical ER (cER) that adheres to the plasma membrane. Delivery of cER from mother cells to buds, which is termed cER inheritance, occurs as an orderly process early in budding. We find that cER inheritance is defective in cells lacking Scs2, a yeast homologue of the integral ER membrane protein VAP (vesicle-associated membrane protein-associated protein) conserved in all eukaryotes. Scs2 and human VAP both target yeast bud tips, suggesting a conserved action of VAP in attaching ER to sites of polarized growth. In addition, the loss of either Scs2 or Ice2 (another protein involved in cER inheritance) perturbs septin assembly at the bud neck. This perturbation leads to a delay in the transition through G2, activating the Saccharomyces wee1 kinase (Swe1) and the morphogenesis checkpoint. 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In budding yeast, the largest subdomain of the endoplasmic reticulum (ER) is a network of cortical ER (cER) that adheres to the plasma membrane. Delivery of cER from mother cells to buds, which is termed cER inheritance, occurs as an orderly process early in budding. We find that cER inheritance is defective in cells lacking Scs2, a yeast homologue of the integral ER membrane protein VAP (vesicle-associated membrane protein-associated protein) conserved in all eukaryotes. Scs2 and human VAP both target yeast bud tips, suggesting a conserved action of VAP in attaching ER to sites of polarized growth. In addition, the loss of either Scs2 or Ice2 (another protein involved in cER inheritance) perturbs septin assembly at the bud neck. This perturbation leads to a delay in the transition through G2, activating the Saccharomyces wee1 kinase (Swe1) and the morphogenesis checkpoint. Thus, we identify a mechanism involved in sensing the distribution of ER.</description><subject>B lymphocytes</subject><subject>Cell cycle</subject><subject>Cell growth</subject><subject>Cell membranes</subject><subject>Cells</subject><subject>Cytoplasmic inheritance</subject><subject>Endoplasmic reticulum</subject><subject>Endoplasmic Reticulum - metabolism</subject><subject>Eukaryotes</subject><subject>Fungal Proteins - metabolism</subject><subject>G2 Phase</subject><subject>Gene Deletion</subject><subject>Gene Targeting</subject><subject>Genetics</subject><subject>Green Fluorescent Proteins - metabolism</subject><subject>Humans</subject><subject>Kinases</subject><subject>Membrane Proteins - metabolism</subject><subject>Microscopy, Electron</subject><subject>Models, Biological</subject><subject>Models, Genetic</subject><subject>Mother cells</subject><subject>Mutation</subject><subject>Plasmids</subject><subject>Proteins</subject><subject>Saccharomyces cerevisiae</subject><subject>Saccharomyces cerevisiae - metabolism</subject><subject>Saccharomyces cerevisiae Proteins - metabolism</subject><subject>Time Factors</subject><subject>Yeast</subject><subject>Yeasts</subject><issn>0021-9525</issn><issn>1540-8140</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0c1rVDEUBfAgih2rS5dqcOHu1ZvPl2wKUqoWioLadbiTyZtmeJNMk_eE-tcbnWH8WGVxfxxOOIQ8Z3DGwIi3G7884wA9GA7qAVkwJaEzTMJDsgDgrLOKqxPypNYNAMheisfkhPXWSMH5gny6SrehxAmTDzQP1OcyRY8jvfxCY6L3AetEY6Ul3M2xhBUdcqEpl20jNeymZnJZY4o_cIo5PSWPBhxreHZ4T8nN-8tvFx-7688fri7eXXdeKTV1DA0yDIFxE5SVaIfQD0ov0VgUA_NWCb3SwWurUYJu3HPjJccl89ArJk7J-T53Ny-3YeVDmgqOblfiFsu9yxjdv5cUb906f3cctOytaAFvDgEl382hTm4bqw_jiCnkuTYnrNWmb_D1f3CT55La5xxnPeOMKdNQt0e-5FpLGI5NGLhfM7k2kzvO1PzLv-v_0YddGnixB5s65XK8CwDF5e_6r_b3AbPDdYnV3XzlwBowXOlei59HBaE-</recordid><startdate>20071105</startdate><enddate>20071105</enddate><creator>Loewen, Christopher J.R</creator><creator>Young, Barry P</creator><creator>Tavassoli, Shabnam</creator><creator>Levine, Timothy P</creator><general>The Rockefeller University Press</general><general>Rockefeller University Press</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20071105</creationdate><title>Inheritance of cortical ER in yeast is required for normal septin organization</title><author>Loewen, Christopher J.R ; 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In budding yeast, the largest subdomain of the endoplasmic reticulum (ER) is a network of cortical ER (cER) that adheres to the plasma membrane. Delivery of cER from mother cells to buds, which is termed cER inheritance, occurs as an orderly process early in budding. We find that cER inheritance is defective in cells lacking Scs2, a yeast homologue of the integral ER membrane protein VAP (vesicle-associated membrane protein-associated protein) conserved in all eukaryotes. Scs2 and human VAP both target yeast bud tips, suggesting a conserved action of VAP in attaching ER to sites of polarized growth. In addition, the loss of either Scs2 or Ice2 (another protein involved in cER inheritance) perturbs septin assembly at the bud neck. This perturbation leads to a delay in the transition through G2, activating the Saccharomyces wee1 kinase (Swe1) and the morphogenesis checkpoint. 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| subjects | B lymphocytes Cell cycle Cell growth Cell membranes Cells Cytoplasmic inheritance Endoplasmic reticulum Endoplasmic Reticulum - metabolism Eukaryotes Fungal Proteins - metabolism G2 Phase Gene Deletion Gene Targeting Genetics Green Fluorescent Proteins - metabolism Humans Kinases Membrane Proteins - metabolism Microscopy, Electron Models, Biological Models, Genetic Mother cells Mutation Plasmids Proteins Saccharomyces cerevisiae Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism Time Factors Yeast Yeasts |
| title | Inheritance of cortical ER in yeast is required for normal septin organization |
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