Requirements for selective recruitment of Ets proteins and activation of mb‐1/Ig‐α gene transcription by Pax‐5 (BSAP)

Pax‐5, a member of the paired domain family of transcription factors, is a key regulator of B lymphocyte‐specific transcription and differentiation. A major target of Pax‐5‐mediated activation is the mb‐1 gene, which encodes the essential transmembrane signaling protein Ig‐α. Pax‐5 recruits three me...

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Veröffentlicht in:	Nucleic acids research 2003-10, Vol.31 (19), p.5483-5489
Hauptverfasser:	Maier, Holly, Ostraat, Rachel, Parenti, Sarah, Fitzsimmons, Daniel, Abraham, Lawrence J., Garvie, Colin W., Hagman, James
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - biosynthesis Antigens, CD - genetics CD79 Antigens Cell Line DNA - chemistry DNA - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Ets-1 protein Fli-1 protein GA-Binding Protein Transcription Factor GABP^a protein Ig-^a gene Macromolecular Substances mb-1 gene Models, Molecular Mutation Pax-5 protein PAX5 Transcription Factor Protein Structure, Secondary Proto-Oncogene Protein c-ets-1 Proto-Oncogene Protein c-fli-1 Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-ets Receptors, Antigen, B-Cell - biosynthesis Receptors, Antigen, B-Cell - genetics Trans-Activators - metabolism Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism Transcriptional Activation
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