Specific inhibition of GPI-anchored protein function by homing and self-association of specific GPI anchors

The functional specificity conferred by glycophosphatidylinositol (GPI) anchors on certain membrane proteins may arise from their occupancy of specific membrane microdomains. We show that membrane proteins with noninteractive external domains attached to the same carcinoembryonic antigen (CEA) GPI a...

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Veröffentlicht in:	The Journal of cell biology 2006-11, Vol.175 (4), p.647-659
Hauptverfasser:	Nicholson, Thomas B, Stanners, Clifford P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - immunology Carcinoembryonic Antigen - chemistry Carcinoembryonic Antigen - metabolism Cell Adhesion - drug effects Cell Differentiation - drug effects Cellular biology CHO Cells Cricetinae Cricetulus Cross-Linking Reagents - pharmacology Extracellular Matrix - drug effects Extracellular Matrix - metabolism Glycosylphosphatidylinositols - antagonists & inhibitors Glycosylphosphatidylinositols - chemistry Glycosylphosphatidylinositols - metabolism Humans Integrins - metabolism Membrane Microdomains - drug effects Membranes Mutant Proteins - metabolism Myoblasts - cytology Myoblasts - drug effects Neural Cell Adhesion Molecules - chemistry Neural Cell Adhesion Molecules - metabolism Protein Binding - drug effects Proteins Rats Studies
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