Conditional deletion of β1 integrins in the intestinal epithelium causes a loss of Hedgehog expression, intestinal hyperplasia, and early postnatal lethality

Conditional deletion of β1 integrins in the intestinal epithelium, unlike in epidermal and mammary epithelia, of mice does not result in decreased cell adhesion and proliferation, but instead causes a profound increase in epithelial proliferation with dysplasia and polypoid structures. The increased...

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Veröffentlicht in:	The Journal of cell biology 2006-11, Vol.175 (3), p.505-514
Hauptverfasser:	Jones, Robert G, Li, Xiufen, Gray, Phillip D, Kuang, Jinqiu, Clayton, Frederic, Samowitz, Wade S, Madison, Blair B, Gumucio, Deborah L, Kuwada, Scott K
Format:	Artikel
Sprache:	eng
Schlagworte:	Caco 2 cells Cell growth Crypts Epithelial cells Gene expression regulation Integrins Intestinal mucosa Intestines Mice Stem cells
Online-Zugang:	Volltext
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