eIF4E is a central node of an RNA regulon that governs cellular proliferation

This study demonstrates that the eukaryotic translation initiation factor eIF4E is a critical node in an RNA regulon that impacts nearly every stage of cell cycle progression. Specifically, eIF4E coordinately promotes the messenger RNA (mRNA) export of several genes involved in the cell cycle. A com...

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Veröffentlicht in:	The Journal of cell biology 2006-11, Vol.175 (3), p.415-426
Hauptverfasser:	Culjkovic, Biljana, Topisirovic, Ivan, Skrabanek, Lucy, Ruiz-Gutierrez, Melisa, Borden, Katherine L.B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell cycle Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell lines Cell Nucleus Structures - metabolism Cell Proliferation Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cyclin D1 - metabolism Cyclins Eukaryotes Eukaryotic Initiation Factor-4E - genetics Eukaryotic Initiation Factor-4E - metabolism Exportin 1 Protein Gene expression regulation Genes Humans Karyopherins Messenger RNA Mice Neoplasm Proteins - metabolism NIH 3T3 Cells Nuclear Proteins - metabolism Nucleocytoplasmic Transport Proteins - metabolism Promyelocytic Leukemia Protein Protein Binding - genetics Protein Biosynthesis Proteins Proto-Oncogene Proteins c-pim-1 - metabolism Receptors, Cytoplasmic and Nuclear Regulon Ribonucleic acid RNA RNA Transport RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins - metabolism Studies Transcription Factors - metabolism Transcription, Genetic Transfection Tumor Suppressor Proteins - metabolism U937 Cells Untranslated regions Untranslated Regions - metabolism
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