actin-based motor protein myosin II regulates MHC class II trafficking and BCR-driven antigen presentation
Antigen (Ag) capture and presentation onto major histocompatibility complex (MHC) class II molecules by B lymphocytes is mediated by their surface Ag receptor (B cell receptor [BCR]). Therefore, the transport of vesicles that carry MHC class II and BCR-Ag complexes must be coordinated for them to co...
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| Veröffentlicht in: | The Journal of cell biology 2007-03, Vol.176 (7), p.1007-1019 |
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| container_title | The Journal of cell biology |
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| creator | Vascotto, Fulvia Lankar, Danielle Faure-André, Gabrielle Vargas, Pablo Diaz, Jheimmy Le Roux, Delphine Yuseff, Maria-Isabel Sibarita, Jean-Baptiste Boes, Marianne Raposo, Graça Mougneau, Evelyne Glaichenhaus, Nicolas Bonnerot, Christian Manoury, Bénédicte Lennon-Duménil, Ana-Maria |
| description | Antigen (Ag) capture and presentation onto major histocompatibility complex (MHC) class II molecules by B lymphocytes is mediated by their surface Ag receptor (B cell receptor [BCR]). Therefore, the transport of vesicles that carry MHC class II and BCR-Ag complexes must be coordinated for them to converge for processing. In this study, we identify the actin-associated motor protein myosin II as being essential for this process. Myosin II is activated upon BCR engagement and associates with MHC class II-invariant chain complexes. Myosin II inhibition or depletion compromises the convergence and concentration of MHC class II and BCR-Ag complexes into lysosomes devoted to Ag processing. Accordingly, the formation of MHC class II-peptides and subsequent CD4 T cell activation are impaired in cells lacking myosin II activity. Therefore, myosin II emerges as a key motor protein in BCR-driven Ag processing and presentation. |
| doi_str_mv | 10.1083/jcb.200611147 |
| format | Article |
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Therefore, the transport of vesicles that carry MHC class II and BCR-Ag complexes must be coordinated for them to converge for processing. In this study, we identify the actin-associated motor protein myosin II as being essential for this process. Myosin II is activated upon BCR engagement and associates with MHC class II-invariant chain complexes. Myosin II inhibition or depletion compromises the convergence and concentration of MHC class II and BCR-Ag complexes into lysosomes devoted to Ag processing. Accordingly, the formation of MHC class II-peptides and subsequent CD4 T cell activation are impaired in cells lacking myosin II activity. Therefore, myosin II emerges as a key motor protein in BCR-driven Ag processing and presentation.</description><identifier>ISSN: 0021-9525</identifier><identifier>EISSN: 1540-8140</identifier><identifier>DOI: 10.1083/jcb.200611147</identifier><identifier>PMID: 17389233</identifier><identifier>CODEN: JCLBA3</identifier><language>eng</language><publisher>United States: The Rockefeller University Press</publisher><subject>Actins ; Actins - metabolism ; Amino acids ; Animals ; Antigen Presentation ; Antigen Presentation - immunology ; Antigens ; B lymphocytes ; B-Lymphocytes - immunology ; B-Lymphocytes - metabolism ; CD4-Positive T-Lymphocytes ; CD4-Positive T-Lymphocytes - immunology ; Cell membranes ; Cells, Cultured ; Histocompatibility Antigens Class II ; Histocompatibility Antigens Class II - immunology ; Histocompatibility Antigens Class II - metabolism ; Immunology ; Life Sciences ; Lymphocyte Activation ; Lymphocyte Activation - immunology ; Lymphocytes ; Lysosomes ; Lysosomes - immunology ; Lysosomes - metabolism ; Macromolecular Substances ; Macromolecular Substances - immunology ; Macromolecular Substances - metabolism ; Mice ; Mice, Transgenic ; Mixed lymphocyte culture test ; Molecules ; Myosin Type II ; Myosin Type II - immunology ; Myosin Type II - metabolism ; Physiological regulation ; Polymers ; Protein Transport ; Protein Transport - immunology ; Proteins ; Receptors, Antigen, B-Cell ; Receptors, Antigen, B-Cell - immunology ; Receptors, Antigen, B-Cell - metabolism ; Small interfering RNA ; Spleen ; Studies ; T cell receptors ; T lymphocytes ; Transport Vesicles ; Transport Vesicles - immunology ; Transport Vesicles - metabolism</subject><ispartof>The Journal of cell biology, 2007-03, Vol.176 (7), p.1007-1019</ispartof><rights>Copyright 2007 The Rockefeller University Press</rights><rights>Copyright Rockefeller University Press Mar 26, 2007</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>Copyright © 2007, The Rockefeller University Press 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c589t-20498426b45174be81985d6b940ce2d00ca3dcf1f6d31d805bd5a20597febe9f3</citedby><cites>FETCH-LOGICAL-c589t-20498426b45174be81985d6b940ce2d00ca3dcf1f6d31d805bd5a20597febe9f3</cites><orcidid>0000-0002-8997-0470 ; 0000-0003-3252-9155 ; 0000-0001-9590-1298 ; 0000-0002-9920-7700</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17389233$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00316389$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Vascotto, Fulvia</creatorcontrib><creatorcontrib>Lankar, Danielle</creatorcontrib><creatorcontrib>Faure-André, Gabrielle</creatorcontrib><creatorcontrib>Vargas, Pablo</creatorcontrib><creatorcontrib>Diaz, Jheimmy</creatorcontrib><creatorcontrib>Le Roux, Delphine</creatorcontrib><creatorcontrib>Yuseff, Maria-Isabel</creatorcontrib><creatorcontrib>Sibarita, Jean-Baptiste</creatorcontrib><creatorcontrib>Boes, Marianne</creatorcontrib><creatorcontrib>Raposo, Graça</creatorcontrib><creatorcontrib>Mougneau, Evelyne</creatorcontrib><creatorcontrib>Glaichenhaus, Nicolas</creatorcontrib><creatorcontrib>Bonnerot, Christian</creatorcontrib><creatorcontrib>Manoury, Bénédicte</creatorcontrib><creatorcontrib>Lennon-Duménil, Ana-Maria</creatorcontrib><title>actin-based motor protein myosin II regulates MHC class II trafficking and BCR-driven antigen presentation</title><title>The Journal of cell biology</title><addtitle>J Cell Biol</addtitle><description>Antigen (Ag) capture and presentation onto major histocompatibility complex (MHC) class II molecules by B lymphocytes is mediated by their surface Ag receptor (B cell receptor [BCR]). Therefore, the transport of vesicles that carry MHC class II and BCR-Ag complexes must be coordinated for them to converge for processing. In this study, we identify the actin-associated motor protein myosin II as being essential for this process. Myosin II is activated upon BCR engagement and associates with MHC class II-invariant chain complexes. Myosin II inhibition or depletion compromises the convergence and concentration of MHC class II and BCR-Ag complexes into lysosomes devoted to Ag processing. Accordingly, the formation of MHC class II-peptides and subsequent CD4 T cell activation are impaired in cells lacking myosin II activity. Therefore, myosin II emerges as a key motor protein in BCR-driven Ag processing and presentation.</description><subject>Actins</subject><subject>Actins - metabolism</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Antigen Presentation</subject><subject>Antigen Presentation - immunology</subject><subject>Antigens</subject><subject>B lymphocytes</subject><subject>B-Lymphocytes - immunology</subject><subject>B-Lymphocytes - metabolism</subject><subject>CD4-Positive T-Lymphocytes</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>Cell membranes</subject><subject>Cells, Cultured</subject><subject>Histocompatibility Antigens Class II</subject><subject>Histocompatibility Antigens Class II - immunology</subject><subject>Histocompatibility Antigens Class II - metabolism</subject><subject>Immunology</subject><subject>Life Sciences</subject><subject>Lymphocyte Activation</subject><subject>Lymphocyte Activation - immunology</subject><subject>Lymphocytes</subject><subject>Lysosomes</subject><subject>Lysosomes - immunology</subject><subject>Lysosomes - metabolism</subject><subject>Macromolecular Substances</subject><subject>Macromolecular Substances - immunology</subject><subject>Macromolecular Substances - metabolism</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Mixed lymphocyte culture test</subject><subject>Molecules</subject><subject>Myosin Type II</subject><subject>Myosin Type II - immunology</subject><subject>Myosin Type II - metabolism</subject><subject>Physiological regulation</subject><subject>Polymers</subject><subject>Protein Transport</subject><subject>Protein Transport - immunology</subject><subject>Proteins</subject><subject>Receptors, Antigen, B-Cell</subject><subject>Receptors, Antigen, B-Cell - immunology</subject><subject>Receptors, Antigen, B-Cell - metabolism</subject><subject>Small interfering RNA</subject><subject>Spleen</subject><subject>Studies</subject><subject>T cell receptors</subject><subject>T lymphocytes</subject><subject>Transport Vesicles</subject><subject>Transport Vesicles - immunology</subject><subject>Transport Vesicles - metabolism</subject><issn>0021-9525</issn><issn>1540-8140</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2P0zAQhiMEYsvCkSMQcUDikGX8lY8L0lIBrVSEBOzZcmwn65DaxXYq7b_HUaoCe-E08szjdzzjN8ueI7hCUJN3g2yvMECJEKLVg2yFGIWiRhQeZisAjIqGYXaRPQlhAABaUfI4u0AVqRtMyCobhIzGFq0IWuV7F53PD95FbWy-v3Mhhe0297qfRhF1yL9s1rkcRQhzOnrRdUb-NLbPhVX5h_W3Qnlz1DYdo-lTPHgdtI0iGmefZo86MQb97BQvs5tPH3-sN8Xu6-ft-npXSFY3scBAm5risqUMVbTVNWpqpsq2oSA1VgBSECU71JWKIFUDaxUTGFhTdbrVTUcus_eL7mFq91rJ1N-LkR-82Qt_x50w_N-KNbe8d0eOoaRQsyTwdhG4vXdtc73jcw6AoDJt8IgS--bUzLtfkw6R702QehyF1W4KvAICZVXi_4JpbGCknsHX98DBTd6mjXGMKoQxbcoEFQskvQvB6-78TgR89gVPvuBnXyT-5d87-UOfjJCAFwswhOSBc53A_BtkFni11DvhuOi9CfzmOwaUgDRdiRH5DUj1xZo</recordid><startdate>20070326</startdate><enddate>20070326</enddate><creator>Vascotto, Fulvia</creator><creator>Lankar, Danielle</creator><creator>Faure-André, Gabrielle</creator><creator>Vargas, Pablo</creator><creator>Diaz, Jheimmy</creator><creator>Le Roux, Delphine</creator><creator>Yuseff, Maria-Isabel</creator><creator>Sibarita, Jean-Baptiste</creator><creator>Boes, Marianne</creator><creator>Raposo, Graça</creator><creator>Mougneau, Evelyne</creator><creator>Glaichenhaus, Nicolas</creator><creator>Bonnerot, Christian</creator><creator>Manoury, Bénédicte</creator><creator>Lennon-Duménil, Ana-Maria</creator><general>The Rockefeller University Press</general><general>Rockefeller University Press</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7T5</scope><scope>7X8</scope><scope>1XC</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8997-0470</orcidid><orcidid>https://orcid.org/0000-0003-3252-9155</orcidid><orcidid>https://orcid.org/0000-0001-9590-1298</orcidid><orcidid>https://orcid.org/0000-0002-9920-7700</orcidid></search><sort><creationdate>20070326</creationdate><title>actin-based motor protein myosin II regulates MHC class II trafficking and BCR-driven antigen presentation</title><author>Vascotto, Fulvia ; Lankar, Danielle ; Faure-André, Gabrielle ; Vargas, Pablo ; Diaz, Jheimmy ; Le Roux, Delphine ; Yuseff, Maria-Isabel ; Sibarita, Jean-Baptiste ; Boes, Marianne ; Raposo, Graça ; Mougneau, Evelyne ; Glaichenhaus, Nicolas ; Bonnerot, Christian ; Manoury, Bénédicte ; Lennon-Duménil, Ana-Maria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c589t-20498426b45174be81985d6b940ce2d00ca3dcf1f6d31d805bd5a20597febe9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Actins</topic><topic>Actins - 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Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vascotto, Fulvia</au><au>Lankar, Danielle</au><au>Faure-André, Gabrielle</au><au>Vargas, Pablo</au><au>Diaz, Jheimmy</au><au>Le Roux, Delphine</au><au>Yuseff, Maria-Isabel</au><au>Sibarita, Jean-Baptiste</au><au>Boes, Marianne</au><au>Raposo, Graça</au><au>Mougneau, Evelyne</au><au>Glaichenhaus, Nicolas</au><au>Bonnerot, Christian</au><au>Manoury, Bénédicte</au><au>Lennon-Duménil, Ana-Maria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>actin-based motor protein myosin II regulates MHC class II trafficking and BCR-driven antigen presentation</atitle><jtitle>The Journal of cell biology</jtitle><addtitle>J Cell Biol</addtitle><date>2007-03-26</date><risdate>2007</risdate><volume>176</volume><issue>7</issue><spage>1007</spage><epage>1019</epage><pages>1007-1019</pages><issn>0021-9525</issn><eissn>1540-8140</eissn><coden>JCLBA3</coden><abstract>Antigen (Ag) capture and presentation onto major histocompatibility complex (MHC) class II molecules by B lymphocytes is mediated by their surface Ag receptor (B cell receptor [BCR]). Therefore, the transport of vesicles that carry MHC class II and BCR-Ag complexes must be coordinated for them to converge for processing. In this study, we identify the actin-associated motor protein myosin II as being essential for this process. Myosin II is activated upon BCR engagement and associates with MHC class II-invariant chain complexes. Myosin II inhibition or depletion compromises the convergence and concentration of MHC class II and BCR-Ag complexes into lysosomes devoted to Ag processing. Accordingly, the formation of MHC class II-peptides and subsequent CD4 T cell activation are impaired in cells lacking myosin II activity. Therefore, myosin II emerges as a key motor protein in BCR-driven Ag processing and presentation.</abstract><cop>United States</cop><pub>The Rockefeller University Press</pub><pmid>17389233</pmid><doi>10.1083/jcb.200611147</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-8997-0470</orcidid><orcidid>https://orcid.org/0000-0003-3252-9155</orcidid><orcidid>https://orcid.org/0000-0001-9590-1298</orcidid><orcidid>https://orcid.org/0000-0002-9920-7700</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of cell biology, 2007-03, Vol.176 (7), p.1007-1019 |
| issn | 0021-9525 1540-8140 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2064085 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Actins Actins - metabolism Amino acids Animals Antigen Presentation Antigen Presentation - immunology Antigens B lymphocytes B-Lymphocytes - immunology B-Lymphocytes - metabolism CD4-Positive T-Lymphocytes CD4-Positive T-Lymphocytes - immunology Cell membranes Cells, Cultured Histocompatibility Antigens Class II Histocompatibility Antigens Class II - immunology Histocompatibility Antigens Class II - metabolism Immunology Life Sciences Lymphocyte Activation Lymphocyte Activation - immunology Lymphocytes Lysosomes Lysosomes - immunology Lysosomes - metabolism Macromolecular Substances Macromolecular Substances - immunology Macromolecular Substances - metabolism Mice Mice, Transgenic Mixed lymphocyte culture test Molecules Myosin Type II Myosin Type II - immunology Myosin Type II - metabolism Physiological regulation Polymers Protein Transport Protein Transport - immunology Proteins Receptors, Antigen, B-Cell Receptors, Antigen, B-Cell - immunology Receptors, Antigen, B-Cell - metabolism Small interfering RNA Spleen Studies T cell receptors T lymphocytes Transport Vesicles Transport Vesicles - immunology Transport Vesicles - metabolism |
| title | actin-based motor protein myosin II regulates MHC class II trafficking and BCR-driven antigen presentation |
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