Paxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamics

Continuous adhesion formation and disassembly (adhesion turnover) in the protrusions of migrating cells is regulated by unclear mechanisms. We show that p21-activated kinase (PAK)-induced phosphorylation of serine 273 in paxillin is a critical regulator of this turnover. Paxillin-S273 phosphorylatio...

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Veröffentlicht in:	The Journal of cell biology 2006-05, Vol.173 (4), p.587-589
Hauptverfasser:	Nayal, Anjana, Webb, Donna J, Brown, Claire M, Schaefer, Erik M, Vicente-Manzanares, Miguel, Horwitz, Alan Rick
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins Amino Acid Sequence - physiology Animals Antibodies Binding sites Cell adhesion Cell adhesion & migration Cell Adhesion - physiology Cell Cycle Proteins - metabolism Cell Membrane - metabolism Cell Movement - physiology Cell Surface Extensions - metabolism Cell Surface Extensions - ultrastructure Cellular biology CHO Cells Cricetinae Feedback, Physiological - physiology Fibroblasts Fibrosis Focal adhesions Guanine Nucleotide Exchange Factors - metabolism Hepatocytes Imaging Macromolecular Substances - metabolism Mutation - genetics Myosin Type II - metabolism p21-Activated Kinases Paxillin - genetics Paxillin - metabolism Phosphoproteins - metabolism Phosphorylation Physiological regulation Protein-Serine-Threonine Kinases - metabolism Proteins rac GTP-Binding Proteins - metabolism Rats Rho Guanine Nucleotide Exchange Factors Serine - metabolism Signal transduction Signal Transduction - physiology
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