Serpin squamous cell carcinoma antigen inhibits UV-induced apoptosis via suppression of c-JUN NH₂-terminal kinase

Protection from ultraviolet (UV) irradiation is a fundamental issue for living organisms. Although melanin's critical role in the protection of basal keratinocytes is well understood, other factors remain essentially unknown. We demonstrate that up-regulation of squamous cell carcinoma antigen-...

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Veröffentlicht in:	The Journal of cell biology 2006-03, Vol.172 (7), p.983-990
Hauptverfasser:	Katagiri, Chika, Nakanishi, Jotaro, Kadoya, Kuniko, Hibino, Toshihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Adult Aged Aged, 80 and over Animals Antigens Antigens, Neoplasm - metabolism Antigens, Neoplasm - pharmacology Antigens, Neoplasm - physiology Apoptosis Apoptosis - drug effects Apoptosis - physiology Apoptosis - radiation effects Cell Line Cell Line, Tumor Cell Nucleus - metabolism Cell Survival - drug effects Cell Survival - genetics Cell Survival - radiation effects Cellular biology Cytoplasm - metabolism Epidermis - drug effects Epidermis - metabolism Epidermis - radiation effects Gene Expression - drug effects Humans Keratinocytes - drug effects Keratinocytes - metabolism Keratinocytes - radiation effects Mice Mice, Transgenic Middle Aged Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors Mitogen-Activated Protein Kinase 8 - metabolism Peptide Fragments - pharmacology Phosphorylation - drug effects Protein Binding - physiology Protein Precursors - genetics Protein Transport - drug effects Protein Transport - radiation effects Proto-Oncogene Proteins c-jun - metabolism RNA, Small Interfering - genetics Serpins - metabolism Serpins - pharmacology Serpins - physiology Skin cancer Transfection Ultraviolet radiation Ultraviolet Rays
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