Mouse embryonic stem cells that express a NUP98-HOXD13 fusion protein are impaired in their ability to differentiate and can be complemented by BCR-ABL

NUP98-HOXD13 (NHD13) fusions have been identified in patients with myelodysplastic syndrome, acute myelogenous leukemia and chronic myeloid leukemia blast crisis. We generated 'knock-in' mouse embryonic stem (ES) cells that express a NHD13 fusion gene from the endogenous murine NUP98 promo...

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Veröffentlicht in:	Leukemia 2007-06, Vol.21 (6), p.1239-1248
Hauptverfasser:	SLAPE, C, CHUNG, Y. J, SOLOWAY, P. D, TESSAROLLO, L, APLAN, P. D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Animals BCR-ABL protein Biological and medical sciences Blast crisis Cancer research Cell culture Cell Culture Techniques Cell Differentiation Cell differentiation, maturation, development, hematopoiesis Cell Line Cell physiology Cell Transformation, Neoplastic - genetics Chronic myeloid leukemia Colonies Colony-stimulating factor Complementation Cytokines Cytology Differentiation Embryo cells Embryonic Stem Cells - cytology Erythropoietin Fundamental and applied biological sciences. Psychology Fusion protein Fusion Proteins, bcr-abl - genetics Gene expression Genetic Complementation Test Granulocyte colony-stimulating factor Granulocyte-macrophage colony-stimulating factor Hematologic and hematopoietic diseases Hematopoietic Stem Cells - cytology Homeodomain Proteins Humans Immunodeficiency Interleukin 3 Leukemia Liquid culture Medical research Medical sciences Mice Mice, Transgenic Molecular and cellular biology Myelodysplastic syndromes Nuclear Pore Complex Proteins Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - physiology Penicillin Proteins Stem cells Transcription Factors Tumors
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