Lack of correlation between thymidylate synthase levels in primary colorectal tumours and subsequent response to chemotherapy

The increasing interest in 5-fluorouracil (5-FU) modulation and the development of new antifolates has focused attention in recent studies on the expression of the target enzyme thymidylate synthase (TS) as a determinant of drug sensitivity and resistance. Resistance to TS-directed drugs has been sh...

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