Novel patterns of p53 abnormality in breast cancer from Taiwan: experience from a low-incidence area
Among 114 breast cancers in Taiwan, the prevalence of p53 mutation (22.8%) and p53 accumulation (38.3%) was similar to that in high-incidence areas. However, novel patterns of p53 abnormalities, including unique sites or types of mutation (i.e. an excessive proportion of G:C to A:T transition at CpG...
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| Veröffentlicht in: | British journal of cancer 1997-01, Vol.75 (5), p.746-751 |
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| container_title | British journal of cancer |
| container_volume | 75 |
| creator | Ann Lou, M Ann Tseng, Su-Ling Chang, Shu-Fen Yue, Chung-Tai Chang, Bao-Li Chou, Chi-How Yang, Show-Lin Teh, Bee-Heong Wu, Cheng-Wen Shen, Chen-Yang |
| description | Among 114 breast cancers in Taiwan, the prevalence of p53 mutation (22.8%) and p53 accumulation (38.3%) was similar to that in high-incidence areas. However, novel patterns of p53 abnormalities, including unique sites or types of mutation (i.e. an excessive proportion of G:C to A:T transition at CpG site), and accumulation of wild-type p53 either within nuclear or cytoplasmic compartments were noted. These may have relevance to breast cancer in Taiwan, a low-incidence area. |
| doi_str_mv | 10.1038/bjc.1997.132 |
| format | Article |
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However, novel patterns of p53 abnormalities, including unique sites or types of mutation (i.e. an excessive proportion of G:C to A:T transition at CpG site), and accumulation of wild-type p53 either within nuclear or cytoplasmic compartments were noted. These may have relevance to breast cancer in Taiwan, a low-incidence area.</description><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Breast Neoplasms - genetics</subject><subject>Cancer Research</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Exons</subject><subject>Genes, p53</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Incidence</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Molecular Medicine</subject><subject>Mutation</subject><subject>Oncology</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Single-Stranded Conformational</subject><subject>Taiwan</subject><subject>Tropical medicine</subject><subject>Tumors</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2PFCEUxInRrOPozasJB-PJHqFpFvCwidn4lWz0sp7Jg369MumGFnp23f9explMNDHxRHj1oygoQp5ztuFM6Ddu6zfcGLXhon1AVlyKtuG6VQ_JijGmGmZa9pg8KWVbt4ZpdUbODOsEE3JF-i_pFkc6w7JgjoWmgc5SUHAx5QnGsNzTEKnLCGWhHqLHTIecJnoN4Q7iW4o_Z8wBq3CYAx3TXROiD_3vIdSjT8mjAcaCz47rmnz78P768lNz9fXj58t3V43vlFoarpxQXHPAzhvuldNOORyEHzrnpO-wE0o63fOu42DO2aCRt8iYVxp6Cb1Yk4uD77xzE_Ye45JhtHMOE-R7myDYv5UYvtubdGtbdi5EJ6rBq6NBTj92WBY7heJxHCFi2hWrtBZSS_NfkEvDuaz0mrw-gD6nUjIOpzSc2X19ttZn9_XZWl_FX_z5ghN87KvqL486FA_jkGsjoZywtkZTfB-vOWClKvEGs92mXY717_997S_PmbMq</recordid><startdate>19970101</startdate><enddate>19970101</enddate><creator>Ann Lou, M Ann</creator><creator>Tseng, Su-Ling</creator><creator>Chang, Shu-Fen</creator><creator>Yue, Chung-Tai</creator><creator>Chang, Bao-Li</creator><creator>Chou, Chi-How</creator><creator>Yang, Show-Lin</creator><creator>Teh, Bee-Heong</creator><creator>Wu, Cheng-Wen</creator><creator>Shen, Chen-Yang</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><general>Nature Publishing Group|1</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19970101</creationdate><title>Novel patterns of p53 abnormality in breast cancer from Taiwan: experience from a low-incidence area</title><author>Ann Lou, M Ann ; Tseng, Su-Ling ; Chang, Shu-Fen ; Yue, Chung-Tai ; Chang, Bao-Li ; Chou, Chi-How ; Yang, Show-Lin ; Teh, Bee-Heong ; Wu, Cheng-Wen ; Shen, Chen-Yang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-17b37181ae4c91c7b8b7bef3cf4bb5c4e4375b8d1441a960f8e12e00c78ad5ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Breast Neoplasms - epidemiology</topic><topic>Breast Neoplasms - genetics</topic><topic>Cancer Research</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Exons</topic><topic>Genes, p53</topic><topic>Gynecology. 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| subjects | Biological and medical sciences Biomedical and Life Sciences Biomedicine Breast Neoplasms - epidemiology Breast Neoplasms - genetics Cancer Research Drug Resistance Epidemiology Exons Genes, p53 Gynecology. Andrology. Obstetrics Humans Incidence Mammary gland diseases Medical sciences Molecular Medicine Mutation Oncology Polymerase Chain Reaction Polymorphism, Single-Stranded Conformational Taiwan Tropical medicine Tumors |
| title | Novel patterns of p53 abnormality in breast cancer from Taiwan: experience from a low-incidence area |
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