Localization of a breast cancer tumour-suppressor gene to a 3-cM interval within chromosomal region 16q22
Allelic losses on chromosome 16q in tumour cells are frequent in a variety of malignancies, suggesting the presence of one or more tumour-suppressor genes in the region. Among 210 sporadic breast cancers we examined using 15 microsatellite markers on the long arm of chromosome 16, heterozygosity for...
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| Veröffentlicht in: | British journal of cancer 1997-01, Vol.75 (2), p.264-267 |
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| creator | Iida, A Isobe, R Yoshimoto, M Kasumi, F Nakamura, Y Emi, M |
| description | Allelic losses on chromosome 16q in tumour cells are frequent in a variety of malignancies, suggesting the presence of one or more tumour-suppressor genes in the region. Among 210 sporadic breast cancers we examined using 15 microsatellite markers on the long arm of chromosome 16, heterozygosity for at least one locus was lost in 141 (67%). Detailed deletion mapping revealed two distinct commonly deleted regions. One region was defined as a 3-cM interval flanked by markers D16S512 and D16S515 at 16q22; the second consisted of a 9.5-cM interval flanked by markers D16S498 and D16S303 at q24.3. Allelic loss on 16q was observed frequently in small tumours, tumours without lymph node metastasis and tumours of the non-invasive histological type as well as in tumours of more advanced phenotype, suggesting that inactivation of one of at least two tumour-suppressor genes on 16q plays a role in early stage breast carcinogenesis. |
| doi_str_mv | 10.1038/bjc.1997.43 |
| format | Article |
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Among 210 sporadic breast cancers we examined using 15 microsatellite markers on the long arm of chromosome 16, heterozygosity for at least one locus was lost in 141 (67%). Detailed deletion mapping revealed two distinct commonly deleted regions. One region was defined as a 3-cM interval flanked by markers D16S512 and D16S515 at 16q22; the second consisted of a 9.5-cM interval flanked by markers D16S498 and D16S303 at q24.3. Allelic loss on 16q was observed frequently in small tumours, tumours without lymph node metastasis and tumours of the non-invasive histological type as well as in tumours of more advanced phenotype, suggesting that inactivation of one of at least two tumour-suppressor genes on 16q plays a role in early stage breast carcinogenesis.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.1997.43</identifier><identifier>PMID: 9010036</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Breast Neoplasms - genetics ; Cancer Research ; Carcinoma, Ductal, Breast - genetics ; Chromosome Mapping ; Chromosomes, Human, Pair 16 ; Drug Resistance ; Epidemiology ; experimental-oncology ; Female ; Genes, Tumor Suppressor ; Gynecology. Andrology. Obstetrics ; Heterozygote ; Humans ; Mammary gland diseases ; Medical sciences ; Microsatellite Repeats ; Molecular Medicine ; Oncology ; Sequence Deletion ; Tumors</subject><ispartof>British journal of cancer, 1997-01, Vol.75 (2), p.264-267</ispartof><rights>Cancer Research Campaign 1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c497t-37c631d70683199073a1e82e439998f42a5b67762b3c06243ee5ddc829cfb2023</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063259/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063259/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,2725,4022,27922,27923,27924,41487,42556,51318,53790,53792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2554437$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9010036$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iida, A</creatorcontrib><creatorcontrib>Isobe, R</creatorcontrib><creatorcontrib>Yoshimoto, M</creatorcontrib><creatorcontrib>Kasumi, F</creatorcontrib><creatorcontrib>Nakamura, Y</creatorcontrib><creatorcontrib>Emi, M</creatorcontrib><title>Localization of a breast cancer tumour-suppressor gene to a 3-cM interval within chromosomal region 16q22</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Allelic losses on chromosome 16q in tumour cells are frequent in a variety of malignancies, suggesting the presence of one or more tumour-suppressor genes in the region. Among 210 sporadic breast cancers we examined using 15 microsatellite markers on the long arm of chromosome 16, heterozygosity for at least one locus was lost in 141 (67%). Detailed deletion mapping revealed two distinct commonly deleted regions. One region was defined as a 3-cM interval flanked by markers D16S512 and D16S515 at 16q22; the second consisted of a 9.5-cM interval flanked by markers D16S498 and D16S303 at q24.3. Allelic loss on 16q was observed frequently in small tumours, tumours without lymph node metastasis and tumours of the non-invasive histological type as well as in tumours of more advanced phenotype, suggesting that inactivation of one of at least two tumour-suppressor genes on 16q plays a role in early stage breast carcinogenesis.</description><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Breast Neoplasms - genetics</subject><subject>Cancer Research</subject><subject>Carcinoma, Ductal, Breast - genetics</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 16</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>experimental-oncology</subject><subject>Female</subject><subject>Genes, Tumor Suppressor</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Heterozygote</subject><subject>Humans</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Microsatellite Repeats</subject><subject>Molecular Medicine</subject><subject>Oncology</subject><subject>Sequence Deletion</subject><subject>Tumors</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kTuPEzEUhS0EWsJCRY1wgWhggh8zfjQroRUvKYgGasvj3EkczdhZ27MIfj0eJYqgoLLs8-mc63sQek7JmhKu3vUHt6Zay3XLH6AV7ThrqGLyIVoRQmRDNCOP0ZOcD_WqiZJX6EoTSggXK-Q30dnR_7bFx4DjgC3uE9hcsLPBQcJlnuKcmjwfjwlyjgnvIAAusZK8cV-xDwXSvR3xT1_2PmC3T3GKOU71KcFusaXijrGn6NFgxwzPzuc1-vHxw_fbz83m26cvt-83jWu1LA2XTnC6lUQoXj9FJLcUFIOWa63V0DLb9UJKwXruiGAtB-i2W6eYdkPPCOPX6Obke5z7CbYOQkl2NMfkJ5t-mWi9-VcJfm928d4wIjjrdDV4fTZI8W6GXMzks4NxtAHinA3tlCKdkBV8cwJdijknGC4hlJilGVObMUszpuWVfvH3XBf2XEXVX511m2slQ6r79_mCsa5rW76Evj1huSphB8kcaj-hbvQ_qS9PeLBlTnCxq8yCVOIPi6ewGg</recordid><startdate>199701</startdate><enddate>199701</enddate><creator>Iida, A</creator><creator>Isobe, R</creator><creator>Yoshimoto, M</creator><creator>Kasumi, F</creator><creator>Nakamura, Y</creator><creator>Emi, M</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><general>Nature Publishing Group|1</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>199701</creationdate><title>Localization of a breast cancer tumour-suppressor gene to a 3-cM interval within chromosomal region 16q22</title><author>Iida, A ; Isobe, R ; Yoshimoto, M ; Kasumi, F ; Nakamura, Y ; Emi, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c497t-37c631d70683199073a1e82e439998f42a5b67762b3c06243ee5ddc829cfb2023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Breast Neoplasms - genetics</topic><topic>Cancer Research</topic><topic>Carcinoma, Ductal, Breast - genetics</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 16</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>experimental-oncology</topic><topic>Female</topic><topic>Genes, Tumor Suppressor</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Heterozygote</topic><topic>Humans</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Microsatellite Repeats</topic><topic>Molecular Medicine</topic><topic>Oncology</topic><topic>Sequence Deletion</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iida, A</creatorcontrib><creatorcontrib>Isobe, R</creatorcontrib><creatorcontrib>Yoshimoto, M</creatorcontrib><creatorcontrib>Kasumi, F</creatorcontrib><creatorcontrib>Nakamura, Y</creatorcontrib><creatorcontrib>Emi, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iida, A</au><au>Isobe, R</au><au>Yoshimoto, M</au><au>Kasumi, F</au><au>Nakamura, Y</au><au>Emi, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Localization of a breast cancer tumour-suppressor gene to a 3-cM interval within chromosomal region 16q22</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>1997-01</date><risdate>1997</risdate><volume>75</volume><issue>2</issue><spage>264</spage><epage>267</epage><pages>264-267</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Allelic losses on chromosome 16q in tumour cells are frequent in a variety of malignancies, suggesting the presence of one or more tumour-suppressor genes in the region. Among 210 sporadic breast cancers we examined using 15 microsatellite markers on the long arm of chromosome 16, heterozygosity for at least one locus was lost in 141 (67%). Detailed deletion mapping revealed two distinct commonly deleted regions. One region was defined as a 3-cM interval flanked by markers D16S512 and D16S515 at 16q22; the second consisted of a 9.5-cM interval flanked by markers D16S498 and D16S303 at q24.3. Allelic loss on 16q was observed frequently in small tumours, tumours without lymph node metastasis and tumours of the non-invasive histological type as well as in tumours of more advanced phenotype, suggesting that inactivation of one of at least two tumour-suppressor genes on 16q plays a role in early stage breast carcinogenesis.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>9010036</pmid><doi>10.1038/bjc.1997.43</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological and medical sciences Biomedical and Life Sciences Biomedicine Breast Neoplasms - genetics Cancer Research Carcinoma, Ductal, Breast - genetics Chromosome Mapping Chromosomes, Human, Pair 16 Drug Resistance Epidemiology experimental-oncology Female Genes, Tumor Suppressor Gynecology. Andrology. Obstetrics Heterozygote Humans Mammary gland diseases Medical sciences Microsatellite Repeats Molecular Medicine Oncology Sequence Deletion Tumors |
| title | Localization of a breast cancer tumour-suppressor gene to a 3-cM interval within chromosomal region 16q22 |
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