Superoxide dismutases in relation to the overall survival of colorectal cancer patients
Reactive oxygen metabolites are implicated in the initiation and promotion of cancer. In addition, oxidant scavengers, such as manganese--(Mn-SOD) and copper/zinc--superoxide dismutase (Cu/Zn-SOD), are thought to contribute to colorectal cancer treatment response. In the present study, the prognosti...
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| Veröffentlicht in: | British journal of cancer 1998-10, Vol.78 (8), p.1051-1057 |
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| creator | Janssen, AML Bosman, CB Sier, CFM Griffioen, G Kubben, FJGM Lamers, CBHW van Krieken, JHJM van de Velde, CJ Verspaget, HW |
| description | Reactive oxygen metabolites are implicated in the initiation and promotion of cancer. In addition, oxidant scavengers, such as manganese--(Mn-SOD) and copper/zinc--superoxide dismutase (Cu/Zn-SOD), are thought to contribute to colorectal cancer treatment response. In the present study, the prognostic significance of the Mn- and Cu/Zn-SOD antigen content of normal mucosa and carcinomas of 163 patients with colorectal cancer was evaluated in comparison with major clinicopathological parameters, with respect to the 5-year overall survival. The Mn-SOD content of carcinomas was found to be significantly higher than that of normal mucosa, whereas there was no difference in the Cu/Zn-SOD content between the normal mucosa and carcinomas. No association was demonstrable between the Mn-SOD and Cu/Zn-SOD content of the tissues and the assessed clinicopathological parameters (gender, age, localization, differentiation grade, diameter and Dukes' stage), with the exception of the Cu/Zn-SOD and the differentiation grade of the carcinomas. Univariate analysis showed that a high Mn-SOD content of carcinomas was associated with a poor 5-year overall survival of the patients with colorectal cancer. Multivariate analysis including all clinicopathological parameters revealed that this Mn-SOD parameter was prognostically independent. The Mn- and Cu/Zn-SOD content of normal mucosa and the Cu/Zn-SOD content of carcinomas were not associated with the overall survival of the patients. In conclusion, this study demonstrates that for patients with colorectal cancer the Mn-SOD content of colorectal carcinomas has a significant prognostic value that is independent from major clinicopathological parameters, including Dukes' stage. |
| doi_str_mv | 10.1038/bjc.1998.626 |
| format | Article |
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In addition, oxidant scavengers, such as manganese--(Mn-SOD) and copper/zinc--superoxide dismutase (Cu/Zn-SOD), are thought to contribute to colorectal cancer treatment response. In the present study, the prognostic significance of the Mn- and Cu/Zn-SOD antigen content of normal mucosa and carcinomas of 163 patients with colorectal cancer was evaluated in comparison with major clinicopathological parameters, with respect to the 5-year overall survival. The Mn-SOD content of carcinomas was found to be significantly higher than that of normal mucosa, whereas there was no difference in the Cu/Zn-SOD content between the normal mucosa and carcinomas. No association was demonstrable between the Mn-SOD and Cu/Zn-SOD content of the tissues and the assessed clinicopathological parameters (gender, age, localization, differentiation grade, diameter and Dukes' stage), with the exception of the Cu/Zn-SOD and the differentiation grade of the carcinomas. Univariate analysis showed that a high Mn-SOD content of carcinomas was associated with a poor 5-year overall survival of the patients with colorectal cancer. Multivariate analysis including all clinicopathological parameters revealed that this Mn-SOD parameter was prognostically independent. The Mn- and Cu/Zn-SOD content of normal mucosa and the Cu/Zn-SOD content of carcinomas were not associated with the overall survival of the patients. In conclusion, this study demonstrates that for patients with colorectal cancer the Mn-SOD content of colorectal carcinomas has a significant prognostic value that is independent from major clinicopathological parameters, including Dukes' stage.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.1998.626</identifier><identifier>PMID: 9792149</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Aged ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Carcinoma - enzymology ; clinical-oncology ; Colorectal Neoplasms - enzymology ; Colorectal Neoplasms - mortality ; Drug Resistance ; Enzyme-Linked Immunosorbent Assay ; Epidemiology ; Female ; Humans ; Intestinal Mucosa - enzymology ; Male ; Molecular Medicine ; Multivariate Analysis ; Oncology ; Prognosis ; Superoxide Dismutase - metabolism</subject><ispartof>British journal of cancer, 1998-10, Vol.78 (8), p.1051-1057</ispartof><rights>Cancer Research Campaign 1998</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063153/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063153/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9792149$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Janssen, AML</creatorcontrib><creatorcontrib>Bosman, CB</creatorcontrib><creatorcontrib>Sier, CFM</creatorcontrib><creatorcontrib>Griffioen, G</creatorcontrib><creatorcontrib>Kubben, FJGM</creatorcontrib><creatorcontrib>Lamers, CBHW</creatorcontrib><creatorcontrib>van Krieken, JHJM</creatorcontrib><creatorcontrib>van de Velde, CJ</creatorcontrib><creatorcontrib>Verspaget, HW</creatorcontrib><title>Superoxide dismutases in relation to the overall survival of colorectal cancer patients</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Reactive oxygen metabolites are implicated in the initiation and promotion of cancer. In addition, oxidant scavengers, such as manganese--(Mn-SOD) and copper/zinc--superoxide dismutase (Cu/Zn-SOD), are thought to contribute to colorectal cancer treatment response. In the present study, the prognostic significance of the Mn- and Cu/Zn-SOD antigen content of normal mucosa and carcinomas of 163 patients with colorectal cancer was evaluated in comparison with major clinicopathological parameters, with respect to the 5-year overall survival. The Mn-SOD content of carcinomas was found to be significantly higher than that of normal mucosa, whereas there was no difference in the Cu/Zn-SOD content between the normal mucosa and carcinomas. No association was demonstrable between the Mn-SOD and Cu/Zn-SOD content of the tissues and the assessed clinicopathological parameters (gender, age, localization, differentiation grade, diameter and Dukes' stage), with the exception of the Cu/Zn-SOD and the differentiation grade of the carcinomas. Univariate analysis showed that a high Mn-SOD content of carcinomas was associated with a poor 5-year overall survival of the patients with colorectal cancer. Multivariate analysis including all clinicopathological parameters revealed that this Mn-SOD parameter was prognostically independent. The Mn- and Cu/Zn-SOD content of normal mucosa and the Cu/Zn-SOD content of carcinomas were not associated with the overall survival of the patients. In conclusion, this study demonstrates that for patients with colorectal cancer the Mn-SOD content of colorectal carcinomas has a significant prognostic value that is independent from major clinicopathological parameters, including Dukes' stage.</description><subject>Aged</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Carcinoma - enzymology</subject><subject>clinical-oncology</subject><subject>Colorectal Neoplasms - enzymology</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Drug Resistance</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Intestinal Mucosa - enzymology</subject><subject>Male</subject><subject>Molecular Medicine</subject><subject>Multivariate Analysis</subject><subject>Oncology</subject><subject>Prognosis</subject><subject>Superoxide Dismutase - metabolism</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUU1LAzEQDaLUWr15FXLytjUf201yEaT4BQUPKh5DNsm2KbubNdld9N-b0iJ6GoY3897MewBcYjTHiPKbcqvnWAg-L0hxBKZ4QUmGOWHHYIoQYhkSBJ2Csxi3qRWIswmYCCYIzsUUfLwOnQ3-yxkLjYvN0KtoI3QtDLZWvfMt7D3sNxb60QZV1zAOYXSjqqGvoPa1D1b3qdOq1TbALu3Yto_n4KRSdbQXhzoD7w_3b8unbPXy-Ly8W2UdobjPigXhGgvKDDGa6ZyKyqSn8oITk-7mDOWCG2PQwmqqy1JjkxNTacYI5QXL6Qzc7nm7oWys0Uk7XSm74BoVvqVXTv5HWreRaz9KggqarEoE1weC4D8HG3vZuKhtXavW-iFKhhBObuI0ePVX6VfiYGXCsz0eE9KubZBbP4Q2PS8xkrukZEpK7pKSKSn6A-bjhqo</recordid><startdate>19981001</startdate><enddate>19981001</enddate><creator>Janssen, AML</creator><creator>Bosman, CB</creator><creator>Sier, CFM</creator><creator>Griffioen, G</creator><creator>Kubben, FJGM</creator><creator>Lamers, CBHW</creator><creator>van Krieken, JHJM</creator><creator>van de Velde, CJ</creator><creator>Verspaget, HW</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group|1</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19981001</creationdate><title>Superoxide dismutases in relation to the overall survival of colorectal cancer patients</title><author>Janssen, AML ; Bosman, CB ; Sier, CFM ; Griffioen, G ; Kubben, FJGM ; Lamers, CBHW ; van Krieken, JHJM ; van de Velde, CJ ; Verspaget, HW</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p231t-6528c1937d2dc7c439fd1034682d092870498ddd05ec3cbbc1d42dfc772386743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Aged</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Carcinoma - enzymology</topic><topic>clinical-oncology</topic><topic>Colorectal Neoplasms - enzymology</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Drug Resistance</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Intestinal Mucosa - enzymology</topic><topic>Male</topic><topic>Molecular Medicine</topic><topic>Multivariate Analysis</topic><topic>Oncology</topic><topic>Prognosis</topic><topic>Superoxide Dismutase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Janssen, AML</creatorcontrib><creatorcontrib>Bosman, CB</creatorcontrib><creatorcontrib>Sier, CFM</creatorcontrib><creatorcontrib>Griffioen, G</creatorcontrib><creatorcontrib>Kubben, FJGM</creatorcontrib><creatorcontrib>Lamers, CBHW</creatorcontrib><creatorcontrib>van Krieken, JHJM</creatorcontrib><creatorcontrib>van de Velde, CJ</creatorcontrib><creatorcontrib>Verspaget, HW</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Janssen, AML</au><au>Bosman, CB</au><au>Sier, CFM</au><au>Griffioen, G</au><au>Kubben, FJGM</au><au>Lamers, CBHW</au><au>van Krieken, JHJM</au><au>van de Velde, CJ</au><au>Verspaget, HW</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Superoxide dismutases in relation to the overall survival of colorectal cancer patients</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>1998-10-01</date><risdate>1998</risdate><volume>78</volume><issue>8</issue><spage>1051</spage><epage>1057</epage><pages>1051-1057</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><abstract>Reactive oxygen metabolites are implicated in the initiation and promotion of cancer. In addition, oxidant scavengers, such as manganese--(Mn-SOD) and copper/zinc--superoxide dismutase (Cu/Zn-SOD), are thought to contribute to colorectal cancer treatment response. In the present study, the prognostic significance of the Mn- and Cu/Zn-SOD antigen content of normal mucosa and carcinomas of 163 patients with colorectal cancer was evaluated in comparison with major clinicopathological parameters, with respect to the 5-year overall survival. The Mn-SOD content of carcinomas was found to be significantly higher than that of normal mucosa, whereas there was no difference in the Cu/Zn-SOD content between the normal mucosa and carcinomas. No association was demonstrable between the Mn-SOD and Cu/Zn-SOD content of the tissues and the assessed clinicopathological parameters (gender, age, localization, differentiation grade, diameter and Dukes' stage), with the exception of the Cu/Zn-SOD and the differentiation grade of the carcinomas. Univariate analysis showed that a high Mn-SOD content of carcinomas was associated with a poor 5-year overall survival of the patients with colorectal cancer. Multivariate analysis including all clinicopathological parameters revealed that this Mn-SOD parameter was prognostically independent. The Mn- and Cu/Zn-SOD content of normal mucosa and the Cu/Zn-SOD content of carcinomas were not associated with the overall survival of the patients. In conclusion, this study demonstrates that for patients with colorectal cancer the Mn-SOD content of colorectal carcinomas has a significant prognostic value that is independent from major clinicopathological parameters, including Dukes' stage.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>9792149</pmid><doi>10.1038/bjc.1998.626</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma - enzymology clinical-oncology Colorectal Neoplasms - enzymology Colorectal Neoplasms - mortality Drug Resistance Enzyme-Linked Immunosorbent Assay Epidemiology Female Humans Intestinal Mucosa - enzymology Male Molecular Medicine Multivariate Analysis Oncology Prognosis Superoxide Dismutase - metabolism |
| title | Superoxide dismutases in relation to the overall survival of colorectal cancer patients |
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