Orthotopic xenografts of human melanoma and colonic and ovarian carcinoma in sheep to evaluate radioimmunotherapy

Extrapolation to humans from experimental radioimmunotherapy in nude mouse xenograft models is confounded by large relative tumour size and small volume of distribution in mice allowing tumour uptake of radiolabelled antibodies unattainable in patients. Our large animal model of human tumours in cyc...

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Veröffentlicht in:	British journal of cancer 1998-08, Vol.78 (4), p.486-494
Hauptverfasser:	Turner, JH, Rose, AH, Glancy, RJ, Penhale, WJ
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - therapy Animal tumors. Experimental tumors Animals Antibodies, Monoclonal - therapeutic use Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Carcinoembryonic Antigen - immunology Colonic Neoplasms - pathology Colonic Neoplasms - therapy Combined treatment Cystadenocarcinoma - therapy Drug Resistance Epidemiology Experimental tumors, general aspects experimental-oncology Female Humans Immunosuppression Iodine Radioisotopes - metabolism Iodine Radioisotopes - therapeutic use Medical sciences Melanoma - pathology Melanoma - therapy Molecular Medicine Neoplasm Transplantation Oncology Ovarian Neoplasms - pathology Ovarian Neoplasms - therapy Radioimmunotherapy Sheep Transplantation, Heterologous Treatment. General aspects Tumor Cells, Cultured Tumors
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