Induction of cell death by stimulation of protein kinase C in human epithelial cells expressing a mutant ras oncogene: a potential therapeutic target

Ras oncogene activation is a key genetic event in several types of human cancer, making its signal pathways an ideal target for novel therapies. We previously showed that expression of mutant ras sensitizes human thyroid epithelial cells to induction of cell death by treatment with phorbol 12-myrist...

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Veröffentlicht in:	British journal of cancer 1998-09, Vol.78 (5), p.641-651
Hauptverfasser:	Hall-Jackson, CA, Jones, T, Eccles, NG, Dawson, TP, Bond, JA, Gescher, A, Wynford-Thomas, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - physiology Biological and medical sciences Biomedical and Life Sciences Biomedicine Blotting, Western Cancer Research Cell Death Cell Line Combined treatment Down-Regulation Drug Resistance Electrophoresis, Agar Gel Epidemiology Epithelial Cells - cytology experimental-oncology Genes, ras Humans Indoles - pharmacology Maleimides - pharmacology Medical sciences Microscopy, Electron Molecular Medicine Mutation Oncology Protein Kinase C - antagonists & inhibitors Protein Kinase C - physiology ras Proteins - physiology Tetradecanoylphorbol Acetate - pharmacology Thyroid Gland - cytology Treatment. General aspects Tumors
Online-Zugang:	Volltext
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