Roflumilast inhibits leukocyte‐endothelial cell interactions, expression of adhesion molecules and microvascular permeability

Background and purpose: The present study addressed the effects of the investigational PDE4 inhibitor roflumilast on leukocyte‐endothelial cell interactions and endothelial permeability in vivo and in vitro. Experimental approach: In vivo, intravital video‐microscopy was used to determine effects of...

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Veröffentlicht in:	British journal of pharmacology 2007-10, Vol.152 (4), p.481-492
Hauptverfasser:	Sanz, M‐J, Cortijo, J, Taha, M A, Cerdá‐Nicolás, M, Schatton, E, Burgbacher, B, Klar, J, Tenor, H, Schudt, C, Issekutz, A C, Hatzelmann, A, Morcillo, E J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopyridines - pharmacology Animals Benzamides - pharmacology Biological and medical sciences Capillary Permeability - drug effects CD11b Antigen - metabolism Cell Adhesion - drug effects Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Cell Communication - drug effects Cell Line Cells, Cultured Cyclopropanes - pharmacology Dose-Response Relationship, Drug Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - metabolism endothelial permeability E‐selectin Humans intravital microscopy Leukocytes - cytology Leukocytes - drug effects leukocyte–endothelial interaction Lipopolysaccharides - antagonists & inhibitors Lipopolysaccharides - pharmacology Male Medical sciences Mesenteric Veins - chemistry Mesenteric Veins - drug effects Mesenteric Veins - metabolism Neutrophils - cytology Neutrophils - drug effects Neutrophils - metabolism PDE4 Pharmacology. Drug treatments Phosphodiesterase Inhibitors - pharmacology P‐selectin Rats Rats, Sprague-Dawley Research Papers Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism roflumilast Selectins - genetics Selectins - metabolism Tumor Necrosis Factor-alpha - pharmacology
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