THE EFFECT OF CHLORPROMAZINE, METYRAPONE, IMIPRAMINE AND SKF 525‐A ON THE HEPATIC FIRST PASS ELIMINATION OF PROPRANOLOL IN THE PITHED RAT

1 The effect of chlorpromazine, metyrapone, imipramine and SKF 525‐A on the hepatic first pass elimination of propranolol has been studied in the pithed rat. 2 The effect of chlorpromazine, metyrapone, imipramine and SKF 525‐A on the inhibition caused by propranolol of an elicited electrically induc...

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Veröffentlicht in:	British journal of pharmacology 1982-12, Vol.77 (4), p.667-677
Hauptverfasser:	BARBER, H.E., KITTERINGHAM, N.R., PETRIE, J.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biotransformation Chlorpromazine - pharmacology Imipramine - pharmacology Kinetics Liver - drug effects Liver - metabolism Male Metyrapone - pharmacology Proadifen - pharmacology Propranolol - metabolism Rats Rats, Inbred Strains Spinal Cord - physiology
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container_title	British journal of pharmacology
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creator	BARBER, H.E. KITTERINGHAM, N.R. PETRIE, J.C.
description	1 The effect of chlorpromazine, metyrapone, imipramine and SKF 525‐A on the hepatic first pass elimination of propranolol has been studied in the pithed rat. 2 The effect of chlorpromazine, metyrapone, imipramine and SKF 525‐A on the inhibition caused by propranolol of an elicited electrically induced tachycardia has also been studied. 3 The hepatic first pass elimination of propranolol was reduced following pretreatment with chlorpromazine, imipramine and SKF 525‐A but was not affected by pretreatment with metyrapone. 4 Chlorpromazine, imipramine and SKF 525‐A all resulted in an increased propranolol blood concentration after hepatic portal vein administration which was associated with decreased formation of metabolites and an enhanced inhibition of an electrically induced tachycardia.
doi_str_mv	10.1111/j.1476-5381.1982.tb09345.x
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KITTERINGHAM, N.R. ; PETRIE, J.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3925-5f5c8ed6dcad35842d9953f2ecd4b678e0927d6f33c939a1b2a45c417058fe253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Animals</topic><topic>Biotransformation</topic><topic>Chlorpromazine - pharmacology</topic><topic>Imipramine - pharmacology</topic><topic>Kinetics</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Metyrapone - pharmacology</topic><topic>Proadifen - pharmacology</topic><topic>Propranolol - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Spinal Cord - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BARBER, H.E.</creatorcontrib><creatorcontrib>KITTERINGHAM, N.R.</creatorcontrib><creatorcontrib>PETRIE, J.C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BARBER, H.E.</au><au>KITTERINGHAM, N.R.</au><au>PETRIE, J.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>THE EFFECT OF CHLORPROMAZINE, METYRAPONE, IMIPRAMINE AND SKF 525‐A ON THE HEPATIC FIRST PASS ELIMINATION OF PROPRANOLOL IN THE PITHED RAT</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>1982-12</date><risdate>1982</risdate><volume>77</volume><issue>4</issue><spage>667</spage><epage>677</epage><pages>667-677</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><abstract>1 The effect of chlorpromazine, metyrapone, imipramine and SKF 525‐A on the hepatic first pass elimination of propranolol has been studied in the pithed rat. 2 The effect of chlorpromazine, metyrapone, imipramine and SKF 525‐A on the inhibition caused by propranolol of an elicited electrically induced tachycardia has also been studied. 3 The hepatic first pass elimination of propranolol was reduced following pretreatment with chlorpromazine, imipramine and SKF 525‐A but was not affected by pretreatment with metyrapone. 4 Chlorpromazine, imipramine and SKF 525‐A all resulted in an increased propranolol blood concentration after hepatic portal vein administration which was associated with decreased formation of metabolites and an enhanced inhibition of an electrically induced tachycardia.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>7150874</pmid><doi>10.1111/j.1476-5381.1982.tb09345.x</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record>
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subjects	Animals Biotransformation Chlorpromazine - pharmacology Imipramine - pharmacology Kinetics Liver - drug effects Liver - metabolism Male Metyrapone - pharmacology Proadifen - pharmacology Propranolol - metabolism Rats Rats, Inbred Strains Spinal Cord - physiology
title	THE EFFECT OF CHLORPROMAZINE, METYRAPONE, IMIPRAMINE AND SKF 525‐A ON THE HEPATIC FIRST PASS ELIMINATION OF PROPRANOLOL IN THE PITHED RAT
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