PERIPHERAL TOXICITY OF HEMICHOLINIUM‐3 IN MICE
1 The site (i.e. peripheral or central) of the toxicity produced by hemicholinium‐3 in mice was investigated. 2 Hemicholinium‐3 was measured fluorometrically and acetylcholine was determined by gas chromatography after intraventricular or intraperitoneal administration of hemicholinium‐3. 3 Hemichol...
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| Veröffentlicht in: | British journal of pharmacology 1982-10, Vol.77 (2), p.239-244 |
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| container_title | British journal of pharmacology |
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| creator | FREEMAN, J.J. KOSH, J.W. PARRISH, J.S. |
| description | 1
The site (i.e. peripheral or central) of the toxicity produced by hemicholinium‐3 in mice was investigated.
2
Hemicholinium‐3 was measured fluorometrically and acetylcholine was determined by gas chromatography after intraventricular or intraperitoneal administration of hemicholinium‐3.
3
Hemicholinium‐3 was not detected in the brain nor were acetylcholine levels decreased in the brain after systemic administration.
4
The dose‐response curve following intraventricular administration demonstrated that hemicholinium‐3 was not as lethal after central administration as it was after peripheral administration.
5
Approximately 24% of a 75 μg intraventricular dose of hemicholinium‐3 was found in the periphery at death.
6
These results suggest that hemicholinium‐3 manifests its toxicity primarily in the periphery. |
| doi_str_mv | 10.1111/j.1476-5381.1982.tb09291.x |
| format | Article |
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The site (i.e. peripheral or central) of the toxicity produced by hemicholinium‐3 in mice was investigated.
2
Hemicholinium‐3 was measured fluorometrically and acetylcholine was determined by gas chromatography after intraventricular or intraperitoneal administration of hemicholinium‐3.
3
Hemicholinium‐3 was not detected in the brain nor were acetylcholine levels decreased in the brain after systemic administration.
4
The dose‐response curve following intraventricular administration demonstrated that hemicholinium‐3 was not as lethal after central administration as it was after peripheral administration.
5
Approximately 24% of a 75 μg intraventricular dose of hemicholinium‐3 was found in the periphery at death.
6
These results suggest that hemicholinium‐3 manifests its toxicity primarily in the periphery.</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/j.1476-5381.1982.tb09291.x</identifier><identifier>PMID: 7139185</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acetylcholine - metabolism ; Animals ; Atropine - pharmacology ; Choline - metabolism ; Hemicholinium 3 - toxicity ; Injections, Intraventricular ; Male ; Mice ; Mice, Inbred ICR ; Respiration - drug effects ; Time Factors</subject><ispartof>British journal of pharmacology, 1982-10, Vol.77 (2), p.239-244</ispartof><rights>1982 British Pharmacological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5081-d5dff80703dd6e1ebcdded5bf7a837834d755214284956a777f02ce4687286ad3</citedby><cites>FETCH-LOGICAL-c5081-d5dff80703dd6e1ebcdded5bf7a837834d755214284956a777f02ce4687286ad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2044599/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2044599/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7139185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FREEMAN, J.J.</creatorcontrib><creatorcontrib>KOSH, J.W.</creatorcontrib><creatorcontrib>PARRISH, J.S.</creatorcontrib><title>PERIPHERAL TOXICITY OF HEMICHOLINIUM‐3 IN MICE</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>1
The site (i.e. peripheral or central) of the toxicity produced by hemicholinium‐3 in mice was investigated.
2
Hemicholinium‐3 was measured fluorometrically and acetylcholine was determined by gas chromatography after intraventricular or intraperitoneal administration of hemicholinium‐3.
3
Hemicholinium‐3 was not detected in the brain nor were acetylcholine levels decreased in the brain after systemic administration.
4
The dose‐response curve following intraventricular administration demonstrated that hemicholinium‐3 was not as lethal after central administration as it was after peripheral administration.
5
Approximately 24% of a 75 μg intraventricular dose of hemicholinium‐3 was found in the periphery at death.
6
These results suggest that hemicholinium‐3 manifests its toxicity primarily in the periphery.</description><subject>Acetylcholine - metabolism</subject><subject>Animals</subject><subject>Atropine - pharmacology</subject><subject>Choline - metabolism</subject><subject>Hemicholinium 3 - toxicity</subject><subject>Injections, Intraventricular</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Respiration - drug effects</subject><subject>Time Factors</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkNFOgzAUhhujmXP6CCbEC-_AllJavNBMwoSEjWXZEr1qgBZlYWPSTbc7H8Fn9EmEjCx6aW9O0--cvycfAFcIGqg-N3MDWdTWCWbIQA4zjXUCHdNBxvYIdA_oGHQhhFRHiLFTcKbUHMIaUtIBHYqwgxjpAjj2JsHY9yb9UJtGT4EbTJ-1aKD53jBw_SgMRsFs-P35hbVgpNVP3jk4yeJCyYu29sBs4E1dXw-jx8Dth3pKIEO6ICLLGKQQC2FLJJNUCClIktGYYcqwJSghJrJMZjnEjimlGTRTadmMmsyOBe6Bu33uapMspEjlcl3FBV9V-SKudryMc_6XLPNX_lK-cxNaFnGcOuC6DajKt41Ua77IVSqLIl7KcqM4wgRTymDdeLtvTKtSqUpmh08Q5I1vPueNVN5I5Y1v3vrm23r48veah9FWcM3v9_wjL-TuH8n8Yew3N_wDRY6NLg</recordid><startdate>198210</startdate><enddate>198210</enddate><creator>FREEMAN, J.J.</creator><creator>KOSH, J.W.</creator><creator>PARRISH, J.S.</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>198210</creationdate><title>PERIPHERAL TOXICITY OF HEMICHOLINIUM‐3 IN MICE</title><author>FREEMAN, J.J. ; KOSH, J.W. ; PARRISH, J.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5081-d5dff80703dd6e1ebcdded5bf7a837834d755214284956a777f02ce4687286ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Acetylcholine - metabolism</topic><topic>Animals</topic><topic>Atropine - pharmacology</topic><topic>Choline - metabolism</topic><topic>Hemicholinium 3 - toxicity</topic><topic>Injections, Intraventricular</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Respiration - drug effects</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FREEMAN, J.J.</creatorcontrib><creatorcontrib>KOSH, J.W.</creatorcontrib><creatorcontrib>PARRISH, J.S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FREEMAN, J.J.</au><au>KOSH, J.W.</au><au>PARRISH, J.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PERIPHERAL TOXICITY OF HEMICHOLINIUM‐3 IN MICE</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>1982-10</date><risdate>1982</risdate><volume>77</volume><issue>2</issue><spage>239</spage><epage>244</epage><pages>239-244</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><abstract>1
The site (i.e. peripheral or central) of the toxicity produced by hemicholinium‐3 in mice was investigated.
2
Hemicholinium‐3 was measured fluorometrically and acetylcholine was determined by gas chromatography after intraventricular or intraperitoneal administration of hemicholinium‐3.
3
Hemicholinium‐3 was not detected in the brain nor were acetylcholine levels decreased in the brain after systemic administration.
4
The dose‐response curve following intraventricular administration demonstrated that hemicholinium‐3 was not as lethal after central administration as it was after peripheral administration.
5
Approximately 24% of a 75 μg intraventricular dose of hemicholinium‐3 was found in the periphery at death.
6
These results suggest that hemicholinium‐3 manifests its toxicity primarily in the periphery.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>7139185</pmid><doi>10.1111/j.1476-5381.1982.tb09291.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of pharmacology, 1982-10, Vol.77 (2), p.239-244 |
| issn | 0007-1188 1476-5381 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Acetylcholine - metabolism Animals Atropine - pharmacology Choline - metabolism Hemicholinium 3 - toxicity Injections, Intraventricular Male Mice Mice, Inbred ICR Respiration - drug effects Time Factors |
| title | PERIPHERAL TOXICITY OF HEMICHOLINIUM‐3 IN MICE |
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