A STUDY OF γ‐AMINOBUTYRIC ACID UPTAKE IN NORMAL AND DOWN'S SYNDROME PLATELETS

1 Initial uptake rates of γ‐aminobutyric acid (GABA) were compared in Down's syndrome (D.S.) and normal platelets. GABA uptake was decreased in D.S. platelets (1.10 ± 0.10 nmol h−1 10−9) compared to uptake by normal platelets (1.89 ± 0.21 nmol h−1 10−9), P < 0.005. 2 The effect of varying th...

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Veröffentlicht in:	British journal of pharmacology 1980-01, Vol.71 (2), p.553-556
Hauptverfasser:	ENNS, LOUISE, McCOY, E.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	2,4-Dinitrophenol Adolescent Blood Platelets - metabolism Cold Temperature Dinitrophenols - pharmacology Down Syndrome - blood gamma-Aminobutyric Acid - blood Humans In Vitro Techniques Kinetics Sodium - physiology Sodium Fluoride - pharmacology
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description	1 Initial uptake rates of γ‐aminobutyric acid (GABA) were compared in Down's syndrome (D.S.) and normal platelets. GABA uptake was decreased in D.S. platelets (1.10 ± 0.10 nmol h−1 10−9) compared to uptake by normal platelets (1.89 ± 0.21 nmol h−1 10−9), P < 0.005. 2 The effect of varying the Na+ concentration was similar on D.S. and normal platelets. Increasing the media Na+ concentration resulted in increased rates of GABA uptake in both D.S. and normal platelets. 3 GABA uptake in the presence of 2,4‐dinitrophenol or at 2°C is approximately 56% of the uptake at 37°C for both D.S. and normal platelets. 4 Extrapolation of a reciprocal plot indicates a two affinity uptake system: a high affinity and a low affinity mechanism. 5 A significant defect in GABA uptake exists in D.S. platelets.
doi_str_mv	10.1111/j.1476-5381.1980.tb10972.x
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Increasing the media Na+ concentration resulted in increased rates of GABA uptake in both D.S. and normal platelets. 3 GABA uptake in the presence of 2,4‐dinitrophenol or at 2°C is approximately 56% of the uptake at 37°C for both D.S. and normal platelets. 4 Extrapolation of a reciprocal plot indicates a two affinity uptake system: a high affinity and a low affinity mechanism. 5 A significant defect in GABA uptake exists in D.S. platelets.</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/j.1476-5381.1980.tb10972.x</identifier><identifier>PMID: 6451255</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>2,4-Dinitrophenol ; Adolescent ; Blood Platelets - metabolism ; Cold Temperature ; Dinitrophenols - pharmacology ; Down Syndrome - blood ; gamma-Aminobutyric Acid - blood ; Humans ; In Vitro Techniques ; Kinetics ; Sodium - physiology ; Sodium Fluoride - pharmacology</subject><ispartof>British journal of pharmacology, 1980-01, Vol.71 (2), p.553-556</ispartof><rights>1980 British Pharmacological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4782-9737ed7e6d5578351a2f6b03ef6e03760ea0200ee8825f4b8c2e3846252390863</citedby><cites>FETCH-LOGICAL-c4782-9737ed7e6d5578351a2f6b03ef6e03760ea0200ee8825f4b8c2e3846252390863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2044451/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2044451/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6451255$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ENNS, LOUISE</creatorcontrib><creatorcontrib>McCOY, E.E.</creatorcontrib><title>A STUDY OF γ‐AMINOBUTYRIC ACID UPTAKE IN NORMAL AND DOWN'S SYNDROME PLATELETS</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>1 Initial uptake rates of γ‐aminobutyric acid (GABA) were compared in Down's syndrome (D.S.) and normal platelets. GABA uptake was decreased in D.S. platelets (1.10 ± 0.10 nmol h−1 10−9) compared to uptake by normal platelets (1.89 ± 0.21 nmol h−1 10−9), P < 0.005. 2 The effect of varying the Na+ concentration was similar on D.S. and normal platelets. Increasing the media Na+ concentration resulted in increased rates of GABA uptake in both D.S. and normal platelets. 3 GABA uptake in the presence of 2,4‐dinitrophenol or at 2°C is approximately 56% of the uptake at 37°C for both D.S. and normal platelets. 4 Extrapolation of a reciprocal plot indicates a two affinity uptake system: a high affinity and a low affinity mechanism. 5 A significant defect in GABA uptake exists in D.S. platelets.</description><subject>2,4-Dinitrophenol</subject><subject>Adolescent</subject><subject>Blood Platelets - metabolism</subject><subject>Cold Temperature</subject><subject>Dinitrophenols - pharmacology</subject><subject>Down Syndrome - blood</subject><subject>gamma-Aminobutyric Acid - blood</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Kinetics</subject><subject>Sodium - physiology</subject><subject>Sodium Fluoride - pharmacology</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkU1u2zAQhYkiQeomPUIBoot0JWX4J9JdFFEsJREiS4Yto_CKkGWqlSFbrmQ3yS5HyF16jx6iJ6kcG0a6LDck8M28Gb6H0EcCNmnPxdwmXDqWYIrYpKvAXk8JdCW1H96gzgEdoQ4ASIsQpd6id00zB2ihFCfoxOGCUCE6aODiUTL2Jji-xr9__Xl6dvtBFF-Nk8kw6GG3F3h4PEjcOx8HEY7iYd8NsRt52Iu_Rp9GeDSJvGHc9_EgdBM_9JPRGTrO07Ix7_f3KRpf-0nv1grjm6DnhlbGpaJWVzJpZtI4MyGkYoKkNHemwEzuGGDSAZMCBTBGKSpyPlUZNUxxhwrKuqAcdoq-7HRXm-nCzDKzXNdpqVd1sUjrR12lhf6XLIvv-lv1U1PgvP19K3C-F6irHxvTrPWiaDJTlunSVJtGS8G5opS3hZ93hVldNU1t8sMQAnqbh57rrel6a7re5qH3eeiHtvnD6zUPrfsAWn654_dFaR7_Q1lfDW5fnuwvyl6Vpw</recordid><startdate>19800101</startdate><enddate>19800101</enddate><creator>ENNS, LOUISE</creator><creator>McCOY, E.E.</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19800101</creationdate><title>A STUDY OF γ‐AMINOBUTYRIC ACID UPTAKE IN NORMAL AND DOWN'S SYNDROME PLATELETS</title><author>ENNS, LOUISE ; McCOY, E.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4782-9737ed7e6d5578351a2f6b03ef6e03760ea0200ee8825f4b8c2e3846252390863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>2,4-Dinitrophenol</topic><topic>Adolescent</topic><topic>Blood Platelets - metabolism</topic><topic>Cold Temperature</topic><topic>Dinitrophenols - pharmacology</topic><topic>Down Syndrome - blood</topic><topic>gamma-Aminobutyric Acid - blood</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Kinetics</topic><topic>Sodium - physiology</topic><topic>Sodium Fluoride - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ENNS, LOUISE</creatorcontrib><creatorcontrib>McCOY, E.E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ENNS, LOUISE</au><au>McCOY, E.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A STUDY OF γ‐AMINOBUTYRIC ACID UPTAKE IN NORMAL AND DOWN'S SYNDROME PLATELETS</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>1980-01-01</date><risdate>1980</risdate><volume>71</volume><issue>2</issue><spage>553</spage><epage>556</epage><pages>553-556</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><abstract>1 Initial uptake rates of γ‐aminobutyric acid (GABA) were compared in Down's syndrome (D.S.) and normal platelets. GABA uptake was decreased in D.S. platelets (1.10 ± 0.10 nmol h−1 10−9) compared to uptake by normal platelets (1.89 ± 0.21 nmol h−1 10−9), P < 0.005. 2 The effect of varying the Na+ concentration was similar on D.S. and normal platelets. Increasing the media Na+ concentration resulted in increased rates of GABA uptake in both D.S. and normal platelets. 3 GABA uptake in the presence of 2,4‐dinitrophenol or at 2°C is approximately 56% of the uptake at 37°C for both D.S. and normal platelets. 4 Extrapolation of a reciprocal plot indicates a two affinity uptake system: a high affinity and a low affinity mechanism. 5 A significant defect in GABA uptake exists in D.S. platelets.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>6451255</pmid><doi>10.1111/j.1476-5381.1980.tb10972.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
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subjects	2,4-Dinitrophenol Adolescent Blood Platelets - metabolism Cold Temperature Dinitrophenols - pharmacology Down Syndrome - blood gamma-Aminobutyric Acid - blood Humans In Vitro Techniques Kinetics Sodium - physiology Sodium Fluoride - pharmacology
title	A STUDY OF γ‐AMINOBUTYRIC ACID UPTAKE IN NORMAL AND DOWN'S SYNDROME PLATELETS
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