BRAIN AND SERUM CALCIUM CONCENTRATIONS FOLLOWING ELECTROCONVULSIVE SHOCK OR BICUCULLINE‐INDUCED CONVULSIONS IN RATS
1 A single electroconvulsive shock (ECS; 125 V, 1 s, 50 Hz) given to rats anaesthetized with halothane produced little change in either serum or regional brain calcium concentrations, compared to rats anaesthetized with halothane, either 5 min or 24 h after the convulsion. Both anaesthetic and ECS‐t...
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| Veröffentlicht in: | British journal of pharmacology 1980-01, Vol.71 (1), p.321-325 |
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| creator | BOWDLER, JULIE M. GREEN, A. RICHARD RAWLE, FRANCES C. |
| description | 1
A single electroconvulsive shock (ECS; 125 V, 1 s, 50 Hz) given to rats anaesthetized with halothane produced little change in either serum or regional brain calcium concentrations, compared to rats anaesthetized with halothane, either 5 min or 24 h after the convulsion. Both anaesthetic and ECS‐treated rats showed an elevated serum concentration 5 min after the ECS.
2
When 5 ECS were given spread out over 10 days there were no significant calcium concentration changes in either serum or brain except for an increase in the pons/medulla.
3
A single convulsion produced by bicuculline (0.375 mg/kg i.v.) resulted in a marked increase in the calcium concentration in serum, but not brain, 5 min later. Diazepam pretreatment (10 mg/kg i.v.) prevented both the convulsion and the serum calcium change.
4
Results are discussed in relation to clinical data on calcium changes following electroconvulsive therapy (ECT) and the enhanced monoamine‐mediated behaviours which follow ECS administration to rats. |
| doi_str_mv | 10.1111/j.1476-5381.1980.tb10942.x |
| format | Article |
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A single electroconvulsive shock (ECS; 125 V, 1 s, 50 Hz) given to rats anaesthetized with halothane produced little change in either serum or regional brain calcium concentrations, compared to rats anaesthetized with halothane, either 5 min or 24 h after the convulsion. Both anaesthetic and ECS‐treated rats showed an elevated serum concentration 5 min after the ECS.
2
When 5 ECS were given spread out over 10 days there were no significant calcium concentration changes in either serum or brain except for an increase in the pons/medulla.
3
A single convulsion produced by bicuculline (0.375 mg/kg i.v.) resulted in a marked increase in the calcium concentration in serum, but not brain, 5 min later. Diazepam pretreatment (10 mg/kg i.v.) prevented both the convulsion and the serum calcium change.
4
Results are discussed in relation to clinical data on calcium changes following electroconvulsive therapy (ECT) and the enhanced monoamine‐mediated behaviours which follow ECS administration to rats.</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/j.1476-5381.1980.tb10942.x</identifier><identifier>PMID: 7470743</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Bicuculline - pharmacology ; Brain Chemistry - drug effects ; Calcium - blood ; Calcium - metabolism ; Electroshock ; In Vitro Techniques ; Male ; Rats ; Seizures - chemically induced ; Seizures - metabolism</subject><ispartof>British journal of pharmacology, 1980-01, Vol.71 (1), p.321-325</ispartof><rights>1980 British Pharmacological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4782-85b75b527d7064cb10beaecca0154e07473101df32c69c6762df73eb46d041683</citedby><cites>FETCH-LOGICAL-c4782-85b75b527d7064cb10beaecca0154e07473101df32c69c6762df73eb46d041683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2044401/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2044401/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,4023,27922,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7470743$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BOWDLER, JULIE M.</creatorcontrib><creatorcontrib>GREEN, A. RICHARD</creatorcontrib><creatorcontrib>RAWLE, FRANCES C.</creatorcontrib><title>BRAIN AND SERUM CALCIUM CONCENTRATIONS FOLLOWING ELECTROCONVULSIVE SHOCK OR BICUCULLINE‐INDUCED CONVULSIONS IN RATS</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>1
A single electroconvulsive shock (ECS; 125 V, 1 s, 50 Hz) given to rats anaesthetized with halothane produced little change in either serum or regional brain calcium concentrations, compared to rats anaesthetized with halothane, either 5 min or 24 h after the convulsion. Both anaesthetic and ECS‐treated rats showed an elevated serum concentration 5 min after the ECS.
2
When 5 ECS were given spread out over 10 days there were no significant calcium concentration changes in either serum or brain except for an increase in the pons/medulla.
3
A single convulsion produced by bicuculline (0.375 mg/kg i.v.) resulted in a marked increase in the calcium concentration in serum, but not brain, 5 min later. Diazepam pretreatment (10 mg/kg i.v.) prevented both the convulsion and the serum calcium change.
4
Results are discussed in relation to clinical data on calcium changes following electroconvulsive therapy (ECT) and the enhanced monoamine‐mediated behaviours which follow ECS administration to rats.</description><subject>Animals</subject><subject>Bicuculline - pharmacology</subject><subject>Brain Chemistry - drug effects</subject><subject>Calcium - blood</subject><subject>Calcium - metabolism</subject><subject>Electroshock</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Rats</subject><subject>Seizures - chemically induced</subject><subject>Seizures - metabolism</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkd9OwjAUxhujQUQfwaTxfrPdunV4YYQyoHFuZmN42exPUQj_soHCnY_gM_okdoJEL-3NafLr952e7wBwhZGO1bme6JhQW7NMB-u46SB9lWLUJIa-OQL1AzoGdYQQ1TB2nFNwVpYThBSkVg3UKKGIErMO1u2wxX3Y8jswcsP4AbKWx3hVA5-5_iBsDXjgR7AbeF7wxP0edD2XDcJA8WHsRXzowqgfsHsYhLDNWcxiz-O--_n-wf1OzNwO_HlZ2ahWyjE6ByejZFrKi31tgLjrDlhf84IeVz_QMkIdQ3OslFqpZdCcIptkashUJjLLEoQtItUA1MQI5yPTyOxmZlPbyEfUlCmxc0Sw7ZgNcLvzXa7TmcwzOV8VyVQsi_EsKbZikYzFXzIfv4jnxaswECEEYWVwszPIikVZFnJ00GIkql2IiagCF1XgotqF2O9CbJT48nf3g3QfvuJ3O_42nsrtP5xF-7H_fTW_AKNMkwM</recordid><startdate>198001</startdate><enddate>198001</enddate><creator>BOWDLER, JULIE M.</creator><creator>GREEN, A. RICHARD</creator><creator>RAWLE, FRANCES C.</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>198001</creationdate><title>BRAIN AND SERUM CALCIUM CONCENTRATIONS FOLLOWING ELECTROCONVULSIVE SHOCK OR BICUCULLINE‐INDUCED CONVULSIONS IN RATS</title><author>BOWDLER, JULIE M. ; GREEN, A. RICHARD ; RAWLE, FRANCES C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4782-85b75b527d7064cb10beaecca0154e07473101df32c69c6762df73eb46d041683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Animals</topic><topic>Bicuculline - pharmacology</topic><topic>Brain Chemistry - drug effects</topic><topic>Calcium - blood</topic><topic>Calcium - metabolism</topic><topic>Electroshock</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Rats</topic><topic>Seizures - chemically induced</topic><topic>Seizures - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BOWDLER, JULIE M.</creatorcontrib><creatorcontrib>GREEN, A. RICHARD</creatorcontrib><creatorcontrib>RAWLE, FRANCES C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BOWDLER, JULIE M.</au><au>GREEN, A. RICHARD</au><au>RAWLE, FRANCES C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BRAIN AND SERUM CALCIUM CONCENTRATIONS FOLLOWING ELECTROCONVULSIVE SHOCK OR BICUCULLINE‐INDUCED CONVULSIONS IN RATS</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>1980-01</date><risdate>1980</risdate><volume>71</volume><issue>1</issue><spage>321</spage><epage>325</epage><pages>321-325</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><abstract>1
A single electroconvulsive shock (ECS; 125 V, 1 s, 50 Hz) given to rats anaesthetized with halothane produced little change in either serum or regional brain calcium concentrations, compared to rats anaesthetized with halothane, either 5 min or 24 h after the convulsion. Both anaesthetic and ECS‐treated rats showed an elevated serum concentration 5 min after the ECS.
2
When 5 ECS were given spread out over 10 days there were no significant calcium concentration changes in either serum or brain except for an increase in the pons/medulla.
3
A single convulsion produced by bicuculline (0.375 mg/kg i.v.) resulted in a marked increase in the calcium concentration in serum, but not brain, 5 min later. Diazepam pretreatment (10 mg/kg i.v.) prevented both the convulsion and the serum calcium change.
4
Results are discussed in relation to clinical data on calcium changes following electroconvulsive therapy (ECT) and the enhanced monoamine‐mediated behaviours which follow ECS administration to rats.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>7470743</pmid><doi>10.1111/j.1476-5381.1980.tb10942.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0007-1188 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Bicuculline - pharmacology Brain Chemistry - drug effects Calcium - blood Calcium - metabolism Electroshock In Vitro Techniques Male Rats Seizures - chemically induced Seizures - metabolism |
| title | BRAIN AND SERUM CALCIUM CONCENTRATIONS FOLLOWING ELECTROCONVULSIVE SHOCK OR BICUCULLINE‐INDUCED CONVULSIONS IN RATS |
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